Evidence map›Paper›PMID 36367084›Full record

ArticleProtein science : a publication of the Protein Society2022

Dynamic regulation of Zn(II) sequestration by calgranulin C.

Qian Wang, Deniz Kuci, Shibani Bhattacharya, Jodi A Hadden-Perilla, Rupal Gupta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Dynamic regulation of Zn(II) sequestration by calgranulin C.Protein science : a publication of the Protein Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qian WangDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York, USA.ORCID 0000-0003-1109-7699
Deniz KuciDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York, USA.
Shibani BhattacharyaNew York Structural Biology Center, New York, New York, USA.ORCID 0000-0002-7706-9167
Jodi A Hadden-PerillaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA.ORCID 0000-0003-4685-8291
Rupal GuptaDepartment of Chemistry, College of Staten Island, City University of New York, New York, New York, USA.ORCID 0000-0001-8637-6129

Funding

This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI SCHMITZ, KARL ROBERT · 2014 to 2024
$26.8M
TR&D4: Integrated pipeline for data analysisP41GM118302 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2017 to 2021
$8.5M
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)- Equipment Supplement RequestRM1GM145397 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI ARTHUR G PALMER · 2022 to 2026
$8.3M
Interdependence of Antimicrobial and Pro-inflammatory Activities Mediated byS100A12 in the Innate Immune ResponseR15GM131338 · NIGMS · COLLEGE OF STATEN ISLAND · PI GUPTA, RUPAL · 2019 to 2022
$936k
NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P41 GM118302NIGMS NIH HHS R15 GM131338NIGMS NIH HHS RM1 GM145397
6 · The paper itself

Abstract

Calgranulin C performs antimicrobial activity in the human immune response by sequestering Zn(II). This biological function is afforded with the aid of two structurally distinct Ca(II)-binding EF hand motifs, wherein one of which bears an unusual amino acid sequence. Here, we utilize solution state NMR relaxation measurements to investigate the mechanism of Ca(II)-modulated enhancement of Zn(II) sequestration by calgranulin C. Using C

Indexed as

Anti-Infective AgentsEF Hand MotifsCalciumHumansLeukocyte L1 Antigen ComplexModels, MolecularProtein ConformationZincAnti-Infective AgentsCalciumLeukocyte L1 Antigen ComplexZincCa(II) binding proteinsmolecular dynamics simulationsNMR spectroscopyzinc sequestration

Identifiers

PMID36367084
PMCPMC9650546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.