Evidence map›Paper›PMID 36366842›Full record

ArticleCombinatorial chemistry & high throughput screening2023

Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4.

Baohai Rong, Xiqi Chen, Guangdong Xie, Letian Han, Hanhan Chen, Qingying Sun, Yongkun Zhou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Baohai RongThe First Clinical Medicine School, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Xiqi ChenDepartment of General Surgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Guangdong XieDepartment of General Surgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Letian HanReproductive and Genetic Center of Integrated Traditional and Western Medicine, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Hanhan ChenDepartment of Breast and Thyroid Surgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Qingying SunDepartment of Breast and Thyroid Surgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Yongkun ZhouDepartment of General Surgery, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250014, China.
Shandong University of Traditional Chinese Medicine · CNAffiliated Hospital of Shandong University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) is the third most common cause of cancer-related death worldwide. Increasing studies have indicated that circular RNAs (circRNAs) play critical roles in cancer progression. However, the precise mechanism and functions of most circRNAs are still unknown in gastric cancer.

methodsIn the present study, we aim to uncover the mechanism by which circRNAs regulate gastric cancer tumorigenesis. By analyzing the microarray data, we screened differential expressed circRNAs in the gastric cancer group and identified a down-regulated circRNA, hsa_circ_0040039 (circSNTB2). Mechanically, circSNTB2 served as a sponge for the miR-6938-5p and up-regulated its expression.

resultsMeanwhile, G0/G1 switch gene 2 (G0S2) and programmed cell death gene 4 (PDCD4) were identified to be the aim genes of miR-6938-5p, constructing circSNTB2/miR-6938-5p/G0S2 and PDCD4 pathways.

conclusionTaken together, our findings demonstrated that circSNTB2 plays an essential role in gastric cancer by regulating miR-6938-5p through G0S2 and PDCD4 genes. CircSNTB2 could be a promising biomarker for GC diagnosis and targeted therapy.

Indexed as

MicroRNAsStomach NeoplasmsApoptosis Regulatory ProteinsCell Cycle ProteinsCell Line, TumorCell ProliferationHumansRNA-Binding ProteinsRNA, CircularApoptosis Regulatory ProteinsCell Cycle ProteinsG0S2 protein, humanMicroRNAsPDCD4 protein, humanRNA-Binding ProteinsRNA, CircularbiomarkercircSNTB2G0S2Gastric cancermiR-6938-5pPDCD4

Identifiers

PMID36366842
PMCPMC10332121
OpenAlexW4308774241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.