Evidence map›Paper›PMID 36366563›Full record

ArticleViruses2022

Genetic Diversity and Possible Origins of the Hepatitis B Virus in Siberian Natives.

Victor Manuylov, Vladimir Chulanov, Ludmila Bezuglova, Elena Chub, Anastasia Karlsen, Karen Kyuregyan, Yulia Ostankova, Alexander Semenov, Ludmila Osipova, Tatjana Tallo and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 2 countries.

Victor ManuylovGamaleya National Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0002-2296-6151
Vladimir ChulanovNational Medical Research Center for Phthisiopulmonology and Infectious Diseases, 127473 Moscow, Russia.ORCID 0000-0001-6303-9293
Ludmila BezuglovaHepatitis B ELISA Department, Vector-Best JSC, 630559 Koltsovo, Russia.
Elena ChubDepartment of Molecular Virology of Flaviviruses and Viral Hepatitis, State Research Center of Virology and Biotechnology "Vector" of the Rospotrednadzor, 630559 Koltsovo, Russia.
Anastasia KarlsenDepartment of Viral Hepatitis, Russian Medical Academy of Continuous Professional Education, 125993 Moscow, Russia.ORCID 0000-0002-6013-7768
Karen KyuregyanDepartment of Viral Hepatitis, Russian Medical Academy of Continuous Professional Education, 125993 Moscow, Russia.ORCID 0000-0002-3599-117X
Yulia OstankovaLaboratory of Molecular Immunology, Institute Pasteur in Saint Petersburg for Research in Epidemiology and Microbiology of the Rospotrednadzor, 197101 Saint-Petersburg, Russia.ORCID 0000-0003-2270-8897
Alexander SemenovEkaterinburg Research Institute of Viral Infections of SRC VB Vector, 620030 Ekaterinburg, Russia.ORCID 0000-0003-3223-8219
Ludmila OsipovaLaboratory of Populational Ethnogenetics, Department of Molecular Diagnostics and Epidemiology, Institute of Cytology and Genetics, 630090 Novosibirsk, Russia.
Tatjana TalloDepartment of Microbiology, Public Health Agency of Sweden, 171 82 Stockholm, Sweden.
Irina NetesovaHepatitis B ELISA Department, Vector-Best JSC, 630559 Koltsovo, Russia.
Artem TkachukGamaleya National Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia.
Vladimir GushchinGamaleya National Research Center of Epidemiology and Microbiology, 123098 Moscow, Russia.ORCID 0000-0002-9397-3762
Sergey NetesovLaboratory of Bionanotechnology, Microbiology and Virology, Novosibirsk State University, 630090 Novosibirsk, Russia.ORCID 0000-0002-7786-2464
Lars O MagniusUlf Lundahl´s Foundation, 100 61 Stockholm, Sweden.
Heléne NorderDepartment of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, 413 90 Gothenburg, Sweden.ORCID 0000-0002-7528-3872
Gamalei Institute of Epidemiology and Microbiology · RUState Research Center of Virology and Biotechnology VECTOR · RUPeoples' Friendship University of Russia · RUEkaterinburg Research Institute of Viral Infections · RUInstitute of Cytology and Genetics · RUNovosibirsk State University · RUPublic Health Agency of Sweden · SESahlgrenska University Hospital · SESaint Petersburg Pasteur Institute · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A total of 381 hepatitis B virus (HBV) DNA sequences collected from nine groups of Siberian native populations were phylogenetically analyzed along with 179 HBV strains sampled in different urban populations of former western USSR republics and 50 strains from Central Asian republics and Mongolia. Different HBV subgenotypes predominated in various native Siberian populations. Subgenotype D1 was dominant in Altaian Kazakhs (100%), Tuvans (100%), and Teleuts (100%) of southern Siberia as well as in Dolgans and Nganasans (69%), who inhabit the polar Taimyr Peninsula. D2 was the most prevalent subgenotype in the combined group of Nenets, Komi, and Khants of the northern Yamalo-Nenets Autonomous Region (71%) and in Yakuts (36%) from northeastern Siberia. D3 was the main subgenotype in South Altaians (76%) and Buryats (40%) of southeastern Siberia, and in Chukchi (51%) of the Russian Far East. Subgenotype C2 was found in Taimyr (19%) and Chukchi (27%), while subgenotype A2 was common in Yakuts (33%). In contrast, D2 was dominant (56%) in urban populations of the former western USSR, and D1 (62%) in Central Asian republics and Mongolia. Statistical analysis demonstrated that the studied groups are epidemiologically isolated from each other and might have contracted HBV from different sources during the settlement of Siberia.

Indexed as

Hepatitis BHepatitis B virusAsian PeopleGenetic VariationGenotypeHumansPhylogenyaboriginal populationgenotypesHBsAg subtypeshepatitis B virusmolecular epidemiologySiberiaSiberian nativessubgenotypes

Identifiers

PMID36366563
PMCPMC9693834
OpenAlexW4308513343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.