Evidence map›Paper›PMID 36366550›Full record

ReviewViruses2022

Antiviral Potential of Natural Resources against Influenza Virus Infections.

Johanna Eichberg, Elena Maiworm, Markus Oberpaul, Volker Czudai-Matwich, Tim Lüddecke, Andreas Vilcinskas, Kornelia Hardes

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Proteomic Analysis of Influenza.Advances in experimental medicine and biology · 2026
    Review
  4. Pharmacophores of Influenza Virus PA Endonuclease Inhibitors.Advances in experimental medicine and biology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Crude Extracts ofViruses · 2023
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Johanna EichbergDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology,Ohlebergsweg 12, 35392 Giessen, Germany.
Elena MaiwormDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology,Ohlebergsweg 12, 35392 Giessen, Germany.
Markus OberpaulDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology,Ohlebergsweg 12, 35392 Giessen, Germany.ORCID 0000-0002-6860-8173
Volker Czudai-MatwichDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology,Ohlebergsweg 12, 35392 Giessen, Germany.
Tim LüddeckeDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology,Ohlebergsweg 12, 35392 Giessen, Germany.ORCID 0000-0002-7234-8685
Andreas VilcinskasDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology,Ohlebergsweg 12, 35392 Giessen, Germany.
Kornelia HardesDepartment of Bioresources, Fraunhofer Institute for Molecular Biology and Applied Ecology,Ohlebergsweg 12, 35392 Giessen, Germany.
Fraunhofer Institute for Molecular Biology and Applied Ecology · DELOEWE Centre for Translational Biodiversity Genomics · DEJustus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza is a severe contagious disease caused by influenza A and B viruses. The WHO estimates that annual outbreaks lead to 3-5 million severe infections of which approximately 10% lead to the death of the patient. While vaccination is the cornerstone of prevention, antiviral drugs represent the most important treatment option of acute infections. Only two classes of drugs are currently approved for the treatment of influenza in numerous countries: M2 channel blockers and neuraminidase inhibitors. In some countries, additional compounds such as the recently developed cap-dependent endonuclease inhibitor baloxavir marboxil or the polymerase inhibitor favipiravir are available. However, many of these compounds suffer from poor efficacy, if not applied early after infection. Furthermore, many influenza strains have developed resistances and lost susceptibility to these compounds. As a result, there is an urgent need to develop new anti-influenza drugs against a broad spectrum of subtypes. Natural products have made an important contribution to the development of new lead structures, particularly in the field of infectious diseases. Therefore, this article aims to review the research on the identification of novel lead structures isolated from natural resources suitable to treat influenza infections.

Indexed as

Influenza, HumanOrthomyxoviridae InfectionsAntiviral AgentsEnzyme InhibitorsHumansNatural ResourcesAntiviral AgentsEnzyme Inhibitorsantimicrobial peptidesantiviral drugsbacteriabio resourcesextractsfungiinfectioninfluenza virusnatural productsvenom

Identifiers

PMID36366550
PMCPMC9693975
OpenAlexW4308454172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.