Evidence map›Paper›PMID 36366545›Full record

ArticleViruses2022

Intra-Patient Evolution of HIV-2 Molecular Properties.

Angelica A Palm, Joakim Esbjörnsson, Anders Kvist, Fredrik Månsson, Antonio Biague, Hans Norrgren, Marianne Jansson, Patrik Medstrand

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Angelica A PalmDepartment of Laboratory Medicine, Lund University, 22184 Lund, Sweden.
Joakim EsbjörnssonDepartment of Translational Medicine, Lund University, 20502 Lund, Sweden.
Anders KvistDepartment of Clinical Sciences, Lund University, 22184 Lund, Sweden.ORCID 0000-0002-1358-0695
Fredrik MånssonDepartment of Translational Medicine, Lund University, 20502 Lund, Sweden.
Antonio BiagueNational Public Health Laboratory, Bissau 1041, Guinea-Bissau.
Hans NorrgrenDepartment of Clinical Sciences, Lund University, 22184 Lund, Sweden.
Marianne JanssonDepartment of Laboratory Medicine, Lund University, 22184 Lund, Sweden.
Patrik MedstrandDepartment of Translational Medicine, Lund University, 20502 Lund, Sweden.
Lund University · SENational Institute of Public Health · GW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited data are available on the pathogenesis of HIV-2, and the evolution of Env molecular properties during disease progression is not fully elucidated. We investigated the intra-patient evolution of molecular properties of HIV-2 Env regions (V1-C3) during the asymptomatic, treatment-naïve phase of the infection in 16 study participants, stratified into faster or slower progressors. Most notably, the rate of change in the number of potential N-linked glycosylation sites (PNGS) within the Env (V1-C3) regions differed between progressor groups. With declining CD4

Indexed as

HIV-1HIV InfectionsHIV SeropositivityDisease ProgressionEvolution, MolecularGlycosylationHIV-2Humanscoreceptordisease progressionevolutionHIV-1HIV-2molecular propertiesPNGS

Identifiers

PMID36366545
PMCPMC9698092
OpenAlexW4308195995

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.