Evidence map›Paper›PMID 36366448›Full record

ArticleViruses2022

Sustained Virologic Suppression Reduces HIV-1 DNA Proviral Levels and HIV Antibodies in Perinatally HIV-Infected Children Followed from Birth.

Trevon Fuller, Tara Kerin, Ruth Cortado, Maria de Lourdes Benamor Teixeira, Maria Isabel Fragoso da Silveira Gouvêa, Christianne Moreira, Maria Leticia Santos Cruz, José Henrique Pilotto, Ivete Gomes, Breno Santos and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Trevon FullerInstitute of the Environment & Sustainability, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-9954-4267
Tara KerinPediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Ruth CortadoPediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Maria de Lourdes Benamor TeixeiraInfectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil.ORCID 0000-0002-6896-0089
Maria Isabel Fragoso da Silveira GouvêaInfectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil.
Christianne MoreiraInfectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil.
Maria Leticia Santos CruzInfectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil.
José Henrique PilottoHospital Geral de Nova Iguaçu, Nova Iguaçu 26030-380, RJ, Brazil.ORCID 0000-0003-0521-8597
Ivete GomesHospital Geral de Nova Iguaçu, Nova Iguaçu 26030-380, RJ, Brazil.
Breno SantosHospital Nossa Senhora da Conceição, Porto Alegre 91350-250, RS, Brazil.
Tauí RochaHospital Nossa Senhora da Conceição, Porto Alegre 91350-250, RS, Brazil.
Priya R SoniCedars Sinai Medical Center, Los Angeles, CA 90048, USA.
Esau JoaoInfectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro 20221-161, RJ, Brazil.ORCID 0000-0002-2412-0627
Myung Shin-SimPediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Yvonne BrysonPediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.
Karin Nielsen-SainesPediatric Infectious Diseases, David Geffen UCLA School of Medicine, Los Angeles, CA 90095, USA.ORCID 0000-0002-1742-5211
University of California, Los Angeles · USHospital Federal dos Servidores do Estado · BRHospital Nossa Senhora da Conceição · BRUniversidade Iguaçu · BRCedars-Sinai Medical Center · US

Funding

Early Antiretroviral Therapy and HIV Remission in Perinatal InfectionR01HD080474 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BRYSON, YVONNE J., LUZURIAGA, KATHERINE F · 2014 to 2018
$6.5M
NIH HHS R01HD080474-01
6 · The paper itself

Abstract

The extent to which perinatally HIV-infected children, following cART initiation, develop a low proviral reservoir burden over time, as measured by HIV DNA droplet-digital polymerase chain reaction (ddPCR) and the effect on HIV antibody is not well characterized. We measured proviral HIV DNA and plasma RNA virus load (VL) in 37 perinatally HIV-infected children at 6 months of age who initiated stable cART. At 6-11 years of age, HIV proviral DNA, HIV VL (RNA), and HIV antibody by Western Blot (WB) were assessed. CART was initiated before 6 months of age in 13 children and after 6 months in 24. At school age, the HIV DNA levels did not differ by the timing of cART, and the HIV DNA levels were lower in children with negative/indeterminate WB (

Indexed as

HIV-1HIV InfectionsChildDNA, ViralHIV AntibodiesHumansInfantProvirusesRNAViral LoadDNA, ViralHIV AntibodiesRNAearly HIV treatmentHIV DNA droplet digital PCRperinatal HIV infectionviral load kineticsviral reservoir burden

Identifiers

PMID36366448
PMCPMC9693172
OpenAlexW4307306604

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.