Evidence map›Paper›PMID 36366406›Full record

ArticleVaccines2022

Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy.

Andrea Costantino, Letizia Morlacchi, Maria Francesca Donato, Andrea Gramegna, Elisa Farina, Clara Dibenedetto, Mariarosaria Campise, Matteo Redaelli, Marta Perego, Carlo Alfieri and 3 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Andrea CostantinoDivision of Gastroenterology and Endoscopy, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20214 Milan, Italy.ORCID 0000-0003-4345-6051
Letizia MorlacchiRespiratory Unit and Adult Cystic Fibrosis Center, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.ORCID 0000-0002-4661-6471
Maria Francesca DonatoDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Andrea GramegnaDepartment of Pathophysiology and Transplantation, Università Degli Studi di Milano, 20124 Milan, Italy.
Elisa FarinaDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Clara DibenedettoDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Mariarosaria CampiseNephrology Dialysis and Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
Matteo RedaelliKidney Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
Marta PeregoKidney Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.ORCID 0000-0002-1981-4122
Carlo AlfieriNephrology Dialysis and Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
Francesco BlasiDepartment of Pathophysiology and Transplantation, Università Degli Studi di Milano, 20124 Milan, Italy.
Pietro LamperticoDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-1026-7476
Evaldo FaviKidney Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.ORCID 0000-0001-6465-428X
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITUniversity of Milan · IT

Funding

Ministero della Salute Current research IRCCS
6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are particularly vulnerable, as the underlying causes of their organ failure and the chronic immunosuppression are associated with a lower immune response to COVID-19 vaccines, and with an excessive risk of death due to SARS-CoV-2 infection. We aimed to evaluate COVID-19 vaccination hesitancy and its reasons in a population of SOTRs.

methodsAll the SOTRs attending our post-transplant clinics were asked to fill in a vaccination status form with specific validated questions related to their willingness to receive a third vaccine dose. In the case of negative answers, the patients were encouraged to explain the reasons for their refusal. Among the SOTRs (1899), 1019 were investigated (53.7%).

resultsOverall, 5.01% (51/1019) of the SOTRs raised concerns regarding the future third dose vaccination. In more detail, hesitancy rates were 3.3% (15/453), 4.2% (7/166), and 7.3% (29/400) among the investigated liver, lung, and kidney transplant recipients, respectively (

conclusionsFull adherence to ongoing or future vaccination campaigns is crucial to prevent, or at least reduce, COVID-19-related morbidity and mortality in fragile patients. The identification of the reasons influencing COVID-19 vaccination hesitancy in these patients is very important to establish appropriate and targeted patient-doctor communication strategies, and to further implement specific vaccination campaigns.

Indexed as

COVID-19COVID-19 vaccinekidney transplantationliver transplantationlung transplantationsolid organ transplant recipientsvaccine hesitancy

Identifiers

PMID36366406
PMCPMC9698445
OpenAlexW4308766984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.