Evidence map›Paper›PMID 36365547›Full record

ArticlePolymers2022

Self-Assembly of Homo- and Hetero-Chiral Cyclodipeptides into Supramolecular Polymers towards Antimicrobial Gels.

Beatrice Rosetti, Erica Scarel, Laura Colomina-Alfaro, Simone Adorinni, Giovanni Pierri, Ottavia Bellotto, Kevin Mamprin, Maurizio Polentarutti, Antonella Bandiera, Consiglia Tedesco and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Peptide-Based Materials That Exploit Metal Coordination.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Beatrice RosettiChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0003-4303-8407
Erica ScarelChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0001-6854-482X
Laura Colomina-AlfaroLife Sciences Department, University of Trieste, 34127 Trieste, Italy.
Simone AdorinniChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0002-6888-7635
Giovanni PierriDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, 84084 Fisciano, Italy.ORCID 0000-0001-5433-6077
Ottavia BellottoChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, Italy.
Kevin MamprinChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, Italy.
Maurizio PolentaruttiElettra-Sincrotrone Trieste, S.S. 114 km 163.5, Basovizza, 34149 Trieste, Italy.
Antonella BandieraLife Sciences Department, University of Trieste, 34127 Trieste, Italy.
Consiglia TedescoDepartment of Chemistry and Biology "A. Zambelli", University of Salerno, 84084 Fisciano, Italy.
Silvia MarchesanChemical and Pharmaceutical Sciences Department, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0001-6089-3873
University of Trieste · ITUniversity of Salerno · ITElettra-Sincrotrone Trieste S.C.p.A. · IT

Funding

European Union 861138University of Trieste FRA2022
6 · The paper itself

Abstract

There is an increasing interest towards the development of new antimicrobial coatings, especially in light of the emergence of antimicrobial resistance (AMR) towards common antibiotics. Cyclodipeptides (CDPs) or diketopiperazines (DKPs) are attractive candidates for their ability to self-assemble into supramolecular polymers and yield gel coatings that do not persist in the environment. In this work, we compare the antimicrobial cyclo(Leu-Phe) with its heterochiral analogs cyclo(D-Leu-L-Phe) and cyclo(L-Leu-D-Phe), as well as cyclo(L-Phe-D-Phe), for their ability to gel. The compounds were synthesized, purified by HPLC, and characterized by

Indexed as

antimicrobialchiralitycyclodipeptidescyclo(Leu-Phe)cyclo(Phe-Phe)D-amino acidsdiketopiperazinesgelspeptidesself-assembly

Identifiers

PMID36365547
PMCPMC9654196
OpenAlexW4307702214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.