Evidence map›Paper›PMID 36365535›Full record

ArticlePolymers2022

Theophylline-Loaded Pectin/Chitosan Hydrochloride Submicron Particles Prepared by Spray Drying with a Continuous Feeding Ultrasonic Atomizer.

Kuo-Chung Cheng, Chia-Chien Hu, Chih-Ying Li, Shih-Chi Li, Zhi-Wei Cai, Yang Wei, Trong-Ming Don

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kuo-Chung ChengDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Chia-Chien HuDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Chih-Ying LiDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Shih-Chi LiDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Zhi-Wei CaiDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Yang WeiDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Trong-Ming DonDepartment of Chemical and Materials Engineering, Tamkang University, New Taipei City 251301, Taiwan.
National Taipei University of Technology · TWTamkang University · TW

Funding

National Taipei University of Technology NTUT-MMH-10108
6 · The paper itself

Abstract

Pectin/chitosan hydrochloride (CHC) particles containing theophylline were prepared by a spray-drying apparatus coupled with a continuous feeding ultrasonic atomizer and a heating column. The formation of the submicron particles was investigated at various compositions of pectin solutions added with a chitosan hydrochloride or calcium chloride solution as a crosslinking agent. Scanning electron microscopic (SEM) images showed the pectin/chitosan hydrochloride particles had spherical and smooth surfaces. Depending on the feeding concentrations, the produced particles had diameters in the range of 300 to 800 nm with a narrow size distribution. Furthermore, the theophylline (TH)-loaded pectin/CHC particles were also prepared by the same apparatus. The TH release from the submicron particles in phosphate-buffered saline at 37 °C was monitored in real-time by a UV-Visible spectrophotometer. The Ritger-Peppas model could well describe the TH release profiles. All the diffusional exponents (

Indexed as

chitosan hydrochloridecontrol releasepectinRitger–Peppas modelspray dryersubmicron particlesultrasonic atomizer

Identifiers

PMID36365535
PMCPMC9655009
OpenAlexW4307550039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.