Evidence map›Paper›PMID 36365315›Full record

ArticlePlants (Basel, Switzerland)2022

In Vitro Cytotoxic Activity of Methanol Extracts of Selected Medicinal Plants Traditionally Used in Mexico against Human Hepatocellular Carcinoma.

Joel H Elizondo-Luévano, Ricardo Gomez-Flores, María J Verde-Star, Patricia Tamez-Guerra, César I Romo-Sáenz, Abelardo Chávez-Montes, Nancy E Rodríguez-Garza, Ramiro Quintanilla-Licea

Abstract read
In one paragraph

Article in Plants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Antibacterial Activity of CuO Nanoparticles, Ethanolic Extract ofInternational journal of nanomedicine · 2025
    Article
  8. Article
  9. Article
  10. In Vitro Antiprotozoal Activity ofPlants (Basel, Switzerland) · 2024
    Article
  11. Assessment of Anticancer Properties ofPlants (Basel, Switzerland) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Biological Activities and Chemical Profiles ofPlants (Basel, Switzerland) · 2023
    Article
  17. Article
  18. Review
  19. Effect of Culture Conditions ofInternational journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joel H Elizondo-LuévanoDepartamento de Química, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.ORCID 0000-0003-2954-5939
Ricardo Gomez-FloresDepartamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.
María J Verde-StarDepartamento de Química, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.
Patricia Tamez-GuerraDepartamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.ORCID 0000-0002-4831-2340
César I Romo-SáenzDepartamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.
Abelardo Chávez-MontesDepartamento de Química, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.
Nancy E Rodríguez-GarzaDepartamento de Química, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.ORCID 0000-0003-3201-5437
Ramiro Quintanilla-LiceaDepartamento de Química, Facultad de Ciencias Biológicas (FCB), Universidad Autónoma de Nuevo León (UANL), San Nicolás de los Garza, N.L., Monterrey 66455, Mexico.ORCID 0000-0002-4379-6913

Funding

Consejo Nacional de Ciencia y Tecnología 808132Consejo Nacional de Ciencia y Tecnología 877783Consejo Nacional de Ciencia y Tecnología 935405
6 · The paper itself

Abstract

Medicinal plants are traditionally used in Mexico to treat diseases such as cancer. The present study aimed to evaluate the cytotoxic, antioxidant, and anti-hemolytic activity of 15 plants of ethnopharmacological use in Mexico. For this, plant methanol extracts were prepared by the Soxhlet method, after which their cytotoxic activity was evaluated against human hepatocellular carcinoma (HEP-G2) and monkey kidney epithelial (Vero) cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction colorimetric assay. The selectivity index (SI) of each extract was then determined by the IC

Indexed as

anticancerantioxidant activitycytotoxic activityhemolytic activitymedicinal plantsMexican ethnobotanyMexican plantsnatural productsphytochemicalsplant extracts

Identifiers

PMID36365315
PMCPMC9659118

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.