Evidence map›Paper›PMID 36365210›Full record

ArticlePharmaceutics2022

Impact of Perfluoropentane Microdroplets Diameter and Concentration on Acoustic Droplet Vaporization Transition Efficiency and Oxygen Scavenging.

Rachel P Benton, Nour Al Rifai, Kateryna Stone, Abigail Clark, Bin Zhang, Kevin J Haworth

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Assessment of Cavitation From DEFINITY and DEFINITY RT.Ultrasound in medicine & biology · 2026
    Article
  2. Article
  3. Article
  4. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  5. Article
  6. Acoustically responsive scaffolds: Unraveling release kinetics and mechanisms for sustained, steady drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel P BentonDepartment of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH 45267, USA.
Nour Al RifaiDepartment of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-3782-3006
Kateryna StoneDepartment of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-4040-8743
Abigail ClarkDepartment of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH 45267, USA.
Bin ZhangCincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Kevin J HaworthDepartment of Internal Medicine, Division of Cardiovascular Health and Disease, University of Cincinnati, Cincinnati, OH 45267, USA.ORCID 0000-0002-6578-2440

Funding

Ultrasound-mediated Controlled Hypoxemic Reperfusion for Inhibition of Reperfusion InjuryR01HL148451 · NHLBI · UNIVERSITY OF CINCINNATI · PI HAWORTH, KEVIN JOSEPH · 2019 to 2023
$3.7M
NHLBI NIH HHS R01 HL148451NIH HHS R01HL148451
6 · The paper itself

Abstract

Acoustic droplet vaporization is the ultrasound-mediated phase change of liquid droplets into gas microbubbles. Following the phase change, oxygen diffuses from the surrounding fluid into the microbubble. An in vitro model was used to study the effects of droplet diameter, the presence of an ultrasound contrast agent, ultrasound duty cycle, and droplet concentration on the magnitude of oxygen scavenging in oxygenated deionized water. Perfluoropentane droplets were manufactured through a microfluidic approach at nominal diameters of 1, 3, 5, 7, 9, and 12 µm and studied at concentrations varying from 5.1 × 10

Indexed as

cavitationintravascular ultrasoundmicrofluidic emulsion manufacturingperfluoropentane microdropletspolydispersityultrasound contrast agentultrasound duty cycle

Identifiers

PMID36365210
PMCPMC9694497

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.