Evidence map›Paper›PMID 36365153›Full record

ArticlePharmaceutics2022

Discovery of Novel Thiosemicarbazides Containing 1,3,5-Triazines Derivatives as Potential Synergists against Fluconazole-Resistant

Fei Xie, Yumeng Hao, Jiacun Liu, Junhe Bao, Tingjunhong Ni, Yu Liu, Xiaochen Chi, Ting Wang, Shichong Yu, Yongsheng Jin and 3 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fei XieDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.ORCID 0000-0002-0427-3802
Yumeng HaoDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Jiacun LiuCenter of New Drug Research, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Junhe BaoDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Tingjunhong NiDepartment of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China.
Yu LiuCenter of New Drug Research, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Xiaochen ChiSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang 110016, China.
Ting WangDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Shichong YuDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Yongsheng JinDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Liping LiDepartment of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, China.
Dazhi ZhangDepartment of Organic Chemistry, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.
Lan YanCenter of New Drug Research, School of Pharmacy, Naval Medical University, No. 325 Guohe Road, Shanghai 200433, China.ORCID 0000-0002-2617-4418

Funding

National Natural Science Foundation of China 81830106National Natural Science Foundation of China 82173786National Natural Science Foundation of China 82173867Shanghai Pujiang Program 21PJD0081
6 · The paper itself

Abstract

The clinical prevalence of antifungal drug resistance has been increasing over recent years, resulting in the failure of treatments. In an attempt to overcome this critical problem, we sought novel synergistic enhancers to restore the effectiveness of fluconazole against resistant

Indexed as

1,3,5-triazinesantifungal activitydrug resistancesynergisticsynthesis

Identifiers

PMID36365153
PMCPMC9693882

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.