Evidence map›Paper›PMID 36365042›Full record

ArticlePathogens (Basel, Switzerland)2022

The Troublesome Ticks Research Protocol: Developing a Comprehensive, Multidiscipline Research Plan for Investigating Human Tick-Associated Disease in Australia.

Amanda D Barbosa, Michelle Long, Wenna Lee, Jill M Austen, Mike Cunneen, Andrew Ratchford, Brian Burns, Prasad Kumarasinghe, Rym Ben-Othman, Tobias R Kollmann and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The BCGMethodsX · 2025
    Article
  2. Article
  3. Article
  4. Xinyang flavivirus, fromThe Journal of general virology · 2024
    Article
  5. Perception of Ticks and Tick-Borne Diseases Worldwide.Pathogens (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Amanda D BarbosaCentre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0003-3289-1445
Michelle LongAustralian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, Australia.
Wenna LeeCentre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0003-0666-1590
Jill M AustenCentre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0002-1826-1634
Mike CunneenThe App Workshop Pty Ltd., Perth, WA 6000, Australia.
Andrew RatchfordEmergency Department, Northern Beaches Hospital, Sydney, NSW 2086, Australia.
Brian BurnsEmergency Department, Northern Beaches Hospital, Sydney, NSW 2086, Australia.ORCID 0000-0002-8794-0710
Prasad KumarasingheSchool of Medicine, University of Western Australia, Crawley, WA 6009, Australia.
Rym Ben-OthmanTelethon Kids Institute, Nedlands, WA 6009, Australia.ORCID 0000-0002-7245-6854
Tobias R KollmannTelethon Kids Institute, Nedlands, WA 6009, Australia.
Cameron R StewartCSIRO Health & Biosecurity, Australian Centre for Disease Preparedness, Geelong, VIC 3220, Australia.
Miles BeamanPathWest Laboratory Medicine, Murdoch, WA 6150, Australia.
Rhys ParrySchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-9238-1952
Roy HallSchool of Chemistry and Molecular Biosciences, University of Queensland, St. Lucia, QLD 4072, Australia.
Ala TaborQueensland Alliance for Agriculture and Food Innovation, Centre of Animal Science, University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-7147-1078
Justine O'DonovanClinical Services and Research, Australian Red Cross Lifeblood, Sydney, NSW 2015, Australia.
Helen M FaddyClinical Services and Research, Australian Red Cross Lifeblood, Sydney, NSW 2015, Australia.ORCID 0000-0002-3446-8248
Marjorie CollinsSchool of Psychology, Murdoch University, Murdoch, WA 6150, Australia.
Allen C ChengSchool of Public Health and Preventive Medicine, Monash University, Clayton, VIC 3800, Australia.
John StenosAustralian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, Australia.
Stephen GravesAustralian Rickettsial Reference Laboratory, University Hospital Geelong, Geelong, VIC 3220, Australia.ORCID 0000-0002-8204-0924
Charlotte L OskamCentre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Murdoch, WA 6150, Australia.
Una M RyanHealth Futures Institute, Murdoch University, Murdoch, WA 6150, Australia.
Peter J IrwinCentre for Biosecurity and One Health, Harry Butler Institute, Murdoch University, Murdoch, WA 6150, Australia.ORCID 0000-0002-0006-8262

Funding

National Health and Medical Research Council APP1169949
6 · The paper itself

Abstract

In Australia, there is a paucity of data about the extent and impact of zoonotic tick-related illnesses. Even less is understood about a multifaceted illness referred to as Debilitating Symptom Complexes Attributed to Ticks (DSCATT). Here, we describe a research plan for investigating the aetiology, pathophysiology, and clinical outcomes of human tick-associated disease in Australia. Our approach focuses on the transmission of potential pathogens and the immunological responses of the patient after a tick bite. The protocol is strengthened by prospective data collection, the recruitment of two external matched control groups, and sophisticated integrative data analysis which, collectively, will allow the robust demonstration of associations between a tick bite and the development of clinical and pathological abnormalities. Various laboratory analyses are performed including metagenomics to investigate the potential transmission of bacteria, protozoa and/or viruses during tick bite. In addition, multi-omics technology is applied to investigate links between host immune responses and potential infectious and non-infectious disease causations. Psychometric profiling is also used to investigate whether psychological attributes influence symptom development. This research will fill important knowledge gaps about tick-borne diseases. Ultimately, we hope the results will promote improved diagnostic outcomes, and inform the safe management and treatment of patients bitten by ticks in Australia.

Indexed as

biomarkersDSCATTLyme disease-like illnesstick-borne diseasetick-borne infectionticks

Identifiers

PMID36365042
PMCPMC9694322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.