Evidence map›Paper›PMID 36364925›Full record

ArticleNutrients2022

Left Ventricular Diastolic Dysfunction in Chronic Kidney Disease Patients Not Treated with Dialysis.

Katarzyna Romejko, Aleksandra Rymarz, Katarzyna Szamotulska, Zbigniew Bartoszewicz, Tomasz Rozmyslowicz, Stanisław Niemczyk

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Katarzyna RomejkoDepartment of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, 128 Szaserów Street, 04-141 Warsaw, Poland.ORCID 0000-0003-1447-2917
Aleksandra RymarzDepartment of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, 128 Szaserów Street, 04-141 Warsaw, Poland.ORCID 0000-0002-1844-9872
Katarzyna SzamotulskaDepartment of Epidemiology and Biostatistics, Institute of Mother and Child, Kasprzaka Street, 17a, 01-211 Warsaw, Poland.
Zbigniew BartoszewiczDepartment of Internal Diseases and Endocrinology, Medical University of Warsaw, 1a Banacha Street, 02-097 Warsaw, Poland.
Tomasz RozmyslowiczDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, R.217 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104, USA.
Stanisław NiemczykDepartment of Internal Diseases, Nephrology and Dialysis, Military Institute of Medicine, 128 Szaserów Street, 04-141 Warsaw, Poland.
Wojskowy Instytut Medycyny Lotniczej · PLMedical University of Warsaw · PLUniversity of Pennsylvania · US

Funding

An internal grant of the Military Institute of Medicine, Warsaw, Poland, protocol code 120/WIM/2018 obtained 22 August 2018. Protocol code 120/WIM/2018 obtained 22 August 2018.
6 · The paper itself

Abstract

backgroundLeft ventricular diastolic dysfunction (LVDD) is observed in the early stages of chronic kidney disease (CKD) and may lead to heart failure with preserved ejection fraction (HFpEF). The purpose of our study was to investigate the association between metabolic, nutritional and inflammatory parameters and LVDD in CKD and non-CKD patients.

methodsTwo groups of patients were recruited to the study: 93 men with CKD and eGFR lower than 60 mL/min/1.73 m

resultsWe observed that elevated serum fibrinogen and glucose concentrations were associated with LVDD independently of CKD status. Serum fibrinogen concentrations increased with the advancement of LVDD. Low albumin concentrations in CKD were related with LVDD. In the control group, lower muscle mass presented as lean tissue index (LTI) and lean tissue mass (LTM), and overhydration were associated with LVDD. In the group of patients without kidney function decrease the OPG concentrations were significantly higher in those with LVDD, and they rose with the advancement of LVDD.

conclusionsElevated inflammatory parameters, increased serum glucose concentrations and worse nutritional status are the states that may impair the diastolic function of the left ventricle in CKD and non-CKD patients. Serum OPG levels are elevated in patients without kidney function decrease and LVDD and its concentrations rise with the advancement of LVDD.

Indexed as

Heart FailureRenal Insufficiency, ChronicVentricular Dysfunction, LeftAlbuminsDiastoleFibrinogenGlucoseHumansMaleRenal DialysisStroke VolumeVentricular Function, LeftAlbuminsFibrinogenGlucosebioimpedance spectroscopychronic kidney diseaseinflammatory parametersleft ventricular diastolic dysfunctionmetabolic

Identifiers

PMID36364925
PMCPMC9655426
OpenAlexW4308206603

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.