Evidence map›Paper›PMID 36364922›Full record

ReviewNutrients2022

Novel Therapeutic Approaches for Mitigating Complications in Short Bowel Syndrome.

Jeffery Bettag, Loren Po, Cassius Cunningham, Rahul Tallam, Kento Kurashima, Aakash Nagarapu, Chelsea Hutchinson, Sylvia Morfin, Mustafa Nazzal, Chien-Jung Lin and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jeffery BettagDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.ORCID 0000-0003-2712-9499
Loren PoDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Cassius CunninghamDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Rahul TallamDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Kento KurashimaDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Aakash NagarapuDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Chelsea HutchinsonDepartment of Surgery, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Sylvia MorfinDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Mustafa NazzalDepartment of Surgery, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Chien-Jung LinDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Amit MathurDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Rajeev AuroraDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.ORCID 0000-0002-6609-6055
Ajay K JainDepartment of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO 63103, USA.
Saint Louis University · US

Funding

The protein tyrosine kinase SYK drives innate immune responses against Alzheimer's DiseaseP01AG078106 · NIA · WASHINGTON UNIVERSITY · PI MARCO COLONNA · 2022 to 2026
$18.4M
The Saint Louis University Component of the NASH CRNU01DK061718 · NIDDK · SAINT LOUIS UNIVERSITY · PI BRENT A NEUSCHWANDER-TETRI · 2002 to 2026
$12.0M
Gut region-specific mechanisms that limit dissemination of microbial signals from the intestineU01AI163064 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2021 to 2025
$2.2M
Role of bile acid receptors FXR and TGR5 in preventing injury in short bowel syndromeR01DK131136 · NIDDK · SAINT LOUIS UNIVERSITY · PI JAIN, AJAY K. · 2021 to 2025
$1.9M
Role of intestinal microbiota in driving injury mechanisms in short bowel syndromeR21AI169487 · NIAID · SAINT LOUIS UNIVERSITY · PI JAIN, AJAY K. · 2022 to 2023
$428k
Role of gut microbiota in total parenteral nutrition associated injuryR03DK121046 · NIDDK · SAINT LOUIS UNIVERSITY · PI JAIN, AJAY K. · 2019 to 2020
$227k
NIAID NIH HHS R21 AI169487NIAID NIH HHS U01 AI163064NIA NIH HHS P01 AG078106NIDDK NIH HHS R01 DK131136NIDDK NIH HHS R03 DK121046NIDDK NIH HHS U01 DK061718
6 · The paper itself

Abstract

Short bowel syndrome (SBS) is a particularly serious condition in which the small intestine does not absorb sufficient nutrients for biological needs, resulting in severe illness and potentially death if not treated. Given the important role of the gut in many signaling cascades throughout the body, SBS results in disruption of many pathways and imbalances in various hormones. Due to the inability to meet sufficient nutritional needs, an intravenous form of nutrition, total parental nutrition (TPN), is administered. However, TPN presents difficulties such as severe liver injury and altered signaling secondary to the continued lack of luminal contents. This manuscript aims to summarize relevant studies into the systemic effects of TPN on systems such as the gut-brain, gut-lung, and gut-liver axis, as well as present novel therapeutics currently under use or investigation as mitigation strategies for TPN induced injury.

Indexed as

Short Bowel SyndromeAnimalsDisease Models, AnimalHumansIntestine, SmallLiverParenteral Nutrition, TotalFGF19FXRGLPgut brain axisgut-liver axislipidsOmega 3parenteral nutritionshort bowel syndrome

Identifiers

PMID36364922
PMCPMC9658734
OpenAlexW4308331398

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.