ArticleNutrients2022
Antioxidant Capacity and Protective Effect of Cow Placenta Extract on D-Galactose-Induced Skin Aging in Mice.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- A self-assembled Dendrobium polysaccharide hydrogel with anti-aging activity via the FOXO signaling pathway.Natural products and bioprospecting · 2026Article
- Effects of cow placenta extract on cognitive function in aged dogs: a randomized controlled trial.Journal of veterinary internal medicine · 2026Article
- Protective Effects of a New Human Placental Extract Against Hair Graying and Chemotherapy-Induced Peripheral Neuropathy.International journal of molecular sciences · 2026Article
- Exploratory evaluation of equine placental extract supplementation on ageing indicators in geriatric dogs: a single-arm pre-post study.BMC veterinary research · 2026Article
- Plantagoside Alleviate Hepatic Inflammation, Oxidative Stress and Histopathological Damage in D-Galactose-Induced Senescent Mice by Modulating Purine Metabolic Pathways.Food science & nutrition · 2025Article
- Cow Placenta Peptides Ameliorate D-Galactose-Induced Intestinal Barrier Damage by Regulating TLR/NF-κB Pathway.Veterinary sciences · 2025Article
- Biological effects of human placental extracts - variations in manufacturing methods and compositions.Frontiers in pharmacology · 2025Review
- Effect of sheep placenta extract on D-galactose-induced aging mouse.Frontiers in pharmacology · 2025Article
- Cow Placenta Extract Ameliorates Cyclophosphamide-Induced Intestinal Damage by Enhancing the Intestinal Barrier, Improving Immune Function, and Restoring Intestinal Microbiota.Veterinary sciences · 2024Article
- Mendelian randomization study to assess causality between diet and phenotype of aging.Asia Pacific journal of clinical nutrition · 2024Article
- Isolation and Characterization of Antioxidant Peptides from Dairy Cow (Antioxidants (Basel, Switzerland) · 2024Article
- Research Progress in Skin Aging, Metabolism, and Related Products.International journal of molecular sciences · 2023Review
- Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Placental extract has been used for skin care and delaying skin aging. Cow placenta is an abundant resource with a large mass, which has not been harnessed effectively. Cow placenta extract (CPE) has the functions of antioxidation, anti-inflammatory, promoting growth and development, and promoting hair growth. However, little is known about the effect of oral administration of cow placenta extract on skin conditions. Therefore, the present study aimed to investigate the antioxidant capacity of CPE in vitro and in vivo and its protective effect on d-galactose (D-gal) induced skin aging in mice. The results showed that CPE had strong free radical scavenging, reducing and metal chelating activities. CPE can increase the activity of catalase (CAT), glutathione peroxidase (GSH-Px), peroxidase (POD), superoxide dismutase (SOD), and the content of glutathione (GSH), decrease the content of malondialdehyde (MDA). Moreover, CPE can decrease the gene and protein expression of matrix metalloproteinase 1a (MMP-1a) and matrix metalloproteinase 3 (MMP-3) and increase the expression of transforming growth factor-β (TGF-β) and tissue inhibitor of metalloproteinase 1 (TIMP-1) of mouse skin. Histopathological analysis showed CPE reduced the collagen damage caused by D-gal, increased collagen synthesis and reduced its degradation to delay skin aging.
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Registered trials
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