Evidence map›Paper›PMID 36364889›Full record

ArticleNutrients2022

The Importance of Nutritional Aspects in the Assessment of Inflammation and Intestinal Barrier in Patients with Inflammatory Bowel Disease.

Olga Kaczmarczyk, Agnieszka Dąbek-Drobny, Agnieszka Piątek-Guziewicz, Michał Woźniakiewicz, Paweł Paśko, Justyna Dobrowolska-Iwanek, Aneta Woźniakiewicz, Aneta Targosz, Agata Ptak-Belowska, Urszula Szczyrk and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Prospective study of an adalimumab combined with partial enteral nutrition in the induction period of Crohn's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  7. Review
  8. Review
  9. Antispasmodic Effect ofMolecules (Basel, Switzerland) · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Olga KaczmarczykDepartment of Gastroenterology and Hepatology, Jagiellonian University Medical College, 31-008 Krakow, Poland.ORCID 0000-0002-6117-5176
Agnieszka Dąbek-DrobnyUnit of Clinical Dietetics, Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, 31-008 Krakow, Poland.
Agnieszka Piątek-GuziewiczDepartment of Gastroenterology and Hepatology, Jagiellonian University Medical College, 31-008 Krakow, Poland.
Michał WoźniakiewiczDepartment of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.ORCID 0000-0002-1348-2884
Paweł PaśkoDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, 31-008 Krakow, Poland.ORCID 0000-0002-4821-4492
Justyna Dobrowolska-IwanekDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, 31-008 Krakow, Poland.
Aneta WoźniakiewiczDepartment of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.
Aneta TargoszDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Krakow, Poland.
Agata Ptak-BelowskaDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Krakow, Poland.ORCID 0000-0002-0294-5185
Urszula SzczyrkDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Krakow, Poland.
Małgorzata StrzałkaDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 31-531 Krakow, Poland.
Paweł ZagrodzkiDepartment of Food Chemistry and Nutrition, Jagiellonian University Medical College, 31-008 Krakow, Poland.ORCID 0000-0002-5101-036X
Małgorzata Zwolińska-WcisłoDepartment of Gastroenterology and Hepatology, Jagiellonian University Medical College, 31-008 Krakow, Poland.
Jagiellonian University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal inflammation in inflammatory bowel disease (IBD) is closely linked to nutrition. This study aimed to evaluate associations between nutritional, inflammatory, and intestinal barrier parameters in patients with IBD. We assessed nutritional status, fecal short-chain fatty acid profile, serum cytokine levels, and mRNA expression of enzymes and tight junction proteins in intestinal biopsies obtained from 35 patients, including 11 patients with inactive IBD, 18 patients with active IBD, and six controls. Patients with active IBD were characterized by hypoalbuminemia, fluctuations in body weight, and restriction of fiber-containing foods. In addition, they had significantly reduced levels of isovaleric acid and tended to have lower levels of butyric, acetic, and propionic acids. Patients with active IBD had higher mRNA expression of peroxisome proliferator-activated receptor γ and inducible nitric oxide synthase, and lower mRNA expression of claudin-2 and zonula occludens-1, compared with patients with inactive IBD. Moreover, patients with a body mass index (BMI) of ≥25 kg/m

Indexed as

Inflammatory Bowel DiseasesIntestinal MucosaBody WeightHumansInflammationRNA, MessengerRNA, Messengerdietary fiberiNOSintestinal inflammationnutritionPPAR-γSCFAsuccinatetight junction proteinsTNF-α

Identifiers

PMID36364889
PMCPMC9658856
OpenAlexW4309091645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.