Evidence map›Paper›PMID 36364763›Full record

Trial reportNutrients2022

Postprandial Responses to a Standardised Meal in Hypertension: The Mediatory Role of Visceral Fat Mass.

Panayiotis Louca, Sarah E Berry, Kate Bermingham, Paul W Franks, Jonathan Wolf, Tim D Spector, Ana M Valdes, Phil Chowienczyk, Cristina Menni

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Panayiotis LoucaDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London SE1 7EH, UK.ORCID 0000-0001-5956-1433
Sarah E BerryDepartment of Nutritional Sciences, King's College London, Franklin Wilkins Building, London SE1 9NH, UK.
Kate BerminghamDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London SE1 7EH, UK.
Paul W FranksGenetic & Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, SE-20502 Malmo, Sweden.
Jonathan WolfZoe, London SE1 7RW, UK.
Tim D SpectorDepartment of Twin Research, King's College London, St Thomas' Hospital Campus, London SE1 7EH, UK.
Ana M ValdesNottingham NIHR Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK.ORCID 0000-0003-1141-4471
Phil ChowienczykVascular Risk & Surgery, King's College London, St Thomas' Hospital Campus, London SE1 7EH, UK.
Cristina MenniDepartment of Nutritional Sciences, King's College London, Franklin Wilkins Building, London SE1 9NH, UK.ORCID 0000-0001-9790-0571
St Thomas' Hospital · GBKing's College London · GBLund University · SEUniversity of Nottingham · GBZOE (United Kingdom) · GB

Funding

British Heart Foundation SP/14/8/31352Chronic Disease Research Foundation 212904/Z/18/ZMedical Research Council MR/M016560/1Wellcome Trust
6 · The paper itself

Abstract

Postprandial insulinaemia, triglyceridaemia and measures of inflammation are thought to be more closely associated with cardiovascular risk than fasting measures. Although hypertension is associated with altered fasting metabolism, it is unknown as to what extent postprandial lipaemic and inflammatory metabolic responses differ between hypertensive and normotensive individuals. Linear models adjusting for age, sex, body mass index (BMI), visceral fat mass (VFM) and multiple testing (false discovery rate), were used to investigate whether hypertensive cases and normotensive controls had different fasting and postprandial (in response to two standardised test meal challenges) lipaemic, glycaemic, insulinaemic, and inflammatory (glycoprotein acetylation (GlycA)) responses in 989 participants from the ZOE PREDICT-1 nutritional intervention study. Compared to normotensive controls, hypertensive individuals had significantly higher fasting and postprandial insulin, triglycerides, and markers of inflammation after adjusting for age, sex, and BMI (effect size: Beta (Standard Error) ranging from 0.17 (0.08),

Indexed as

HypertensionIntra-Abdominal FatBlood GlucoseHumansInflammationInsulinPostprandial PeriodTriglyceridesBlood GlucoseInsulinTriglycerideshypertensioninflammationinsulinaemiapostprandialtriglyceridaemia

Identifiers

PMID36364763
PMCPMC9655022
OpenAlexW4307547404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.