ArticleNutrients2022
Phosphate Dysregulation and Metabolic Syndrome.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- The Hidden Burden of Water-Binding Additives in Meat Products: Biochemical, Clinical, and Psychosocial Implications.Molecular nutrition & food research · 2026Review
- Calcidiol Status and Metabolic Syndrome in 40-60-Year-Old Women: Association with Metabolic Components.Nutrients · 2026Article
- Factors linked to tigecycline-associated acute pancreatitis in a multicenter retrospective nested case-control study in patients.iScience · 2026Article
- MAP kinase phosphatases in metabolic diseases.Trends in endocrinology and metabolism: TEM · 2026Review
- Phosphorus Metabolism and Function in Ruminants: Current Knowledge.Animals : an open access journal from MDPI · 2026Review
- Glucagon-Like Peptide-1: The Role of Calcium in Gut-Glucose Axis.Advances in experimental medicine and biology · 2026Review
- Elucidating the Anti-Diabetic Mechanisms of Mushroom Chaga (International journal of molecular sciences · 2025Article
- Minerals and Human Health: From Deficiency to Toxicity.Nutrients · 2025Review
- Metabolic syndrome: risk factors and molecular drug targets.EXCLI journal · 2025Review
- Maternal Metal Ion Status Along Pregnancy and Perinatal Outcomes in a Group of Mexican Women.International journal of molecular sciences · 2024Article
- Associations of phosphorus concentrations with medial arterial calcification in lower-extremity arteries and diabetic foot in people with diabetes: a retrospective cross-sectional study.Cardiovascular diabetology · 2024Article
- The role of magnesium in pancreatic beta-cell function and homeostasis.Frontiers in nutrition · 2024Review
- Editorial: Endocrine regulation of mineral ions and their relevance to metabolic diseases.Frontiers in endocrinology · 2024Article
- Article
- Changing trend of neonatal Ca/P/Mg status in a Chinese population.Translational pediatrics · 2023Article
- Editorial: Value-based nutritional intervention to reduce the progression of chronic human diseases.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual's risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.