Evidence map›Paper›PMID 36364730›Full record

ArticleNutrients2022

Preventive Mechanism of Lycopene on Intestinal Toxicity Caused by Cyclophosphamide Chemotherapy in Mice by Regulating TLR4-MyD88/TRIF-TRAF6 Signaling Pathway and Gut-Liver Axis.

Xiao Pan, Xiaoyan Niu, Yaping Li, Yupei Yao, Lirong Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Acta pharmaceutica Sinica. B · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Effects of Dietary Pretreatment with All-Foods (Basel, Switzerland) · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xiao PanKey Laboratory of Public Health Safety of Hebei Province, Ministry of Education, College of Public Health, Hebei University, Baoding 071002, China.
Xiaoyan NiuKey Laboratory of Public Health Safety of Hebei Province, Ministry of Education, College of Public Health, Hebei University, Baoding 071002, China.
Yaping LiKey Laboratory of Public Health Safety of Hebei Province, Ministry of Education, College of Public Health, Hebei University, Baoding 071002, China.
Yupei YaoKey Laboratory of Public Health Safety of Hebei Province, Ministry of Education, College of Public Health, Hebei University, Baoding 071002, China.
Lirong HanKey Laboratory of Public Health Safety of Hebei Province, Ministry of Education, College of Public Health, Hebei University, Baoding 071002, China.ORCID 0000-0002-3290-5897
Hebei University · CN

Funding

High level Talents Research Start up Project of Hebei University 521000981372Medical Science Foundation of Hebei University 2020B23Medical Science Foundation of Hebei University 2020B25National Natural Science Foundation of China 82204040Natural Science Foundation of Hebei Province B2020201008Natural Science Foundation of Hebei Province C2022201003
6 · The paper itself

Abstract

Cyclophosphamide (CYC) is the first-line chemotherapy drug for cancer in clinical practice, and its intestinal toxicity seriously affects the treatment effect and prognosis of patients. Lycopene (LP) is the main pigment of ripe tomatoes and has strong antioxidant activity. However, the mechanism by which LP prevents CYC-induced intestinal injury remains unclear. The aim of this study was to investigate the mechanism of LP in preventing intestinal toxicity caused by CYC chemotherapy in mice. The results showed that LP significantly prevented spleen and thymus atrophy induced by CYC. In terms of intestinal injury, LP significantly increased the levels of superoxide dismutase (SOD), secretory immunoglobulin A (sIgA), interleukin (IL)-4, IL-12, and interferon (IFN)-γ, decreased the content of lipid oxidation (MDA), upregulated the protein expressions of toll-like receptors 4 (TLR4), myeloid differentiation factor 88 (MyD88), tumor necrosis factor receptor-associated factor 6 (TRAF6), toll/IL-1receptor domain containing adaptor protein inducing IFN-β (TRIF),

Indexed as

Myeloid Differentiation Factor 88TNF Receptor-Associated Factor 6Adaptor Proteins, Vesicular TransportAnimalsCyclophosphamideIntestinesLiverLycopeneMiceNF-kappa BSignal TransductionToll-Like Receptor 4Tumor Necrosis Factor-alphaAdaptor Proteins, Vesicular TransportCyclophosphamideLycopeneMyd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, mouseTNF Receptor-Associated Factor 6Toll-Like Receptor 4Tumor Necrosis Factor-alphacyclophosphamidegut-liver axisintestinal microbiotalycopeneTLR4-MyD88/TRIF-TRAF6 signaling pathway

Identifiers

PMID36364730
PMCPMC9655337
OpenAlexW4307262503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.