ReviewNutrients2022
Is the Use of Artificial Sweeteners Beneficial for Patients with Diabetes Mellitus? The Advantages and Disadvantages of Artificial Sweeteners.
Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Health Effects of Sugar-Sweetened and Artificially Sweetened Beverages: Umbrella Review and Evidence-Based Consensus Statement of the Korean Diabetes Association and the Korean Nutrition Society.Diabetes & metabolism journal · 2026Pooled it
- Trial
- Evaluation of Tooth Erosion Potential of Zero and Carbonated Beverages in Korea: A Laboratory-Based Study Focused on pH.International journal of dental hygiene · 2026Article
- Association of diet with intestinal permeability and inflammation markers in patients with type 1 diabetes.Biomedical reports · 2026Article
- Household Composition May Modify the Association Between Home Cooking and Dietary Diversity Among Japanese Corporate Employees.Nutrients · 2026Article
- Artificial Sweeteners Induce Bacterial Drug Resistance and Modulate Gene Expression.Infection and drug resistance · 2026Article
- Exploring the Anthelmintic and Antidiabetic Effects of Rosarin in Preclinical Studies Using Zebrafish and Earthworm Models (Current diabetes reviews · 2026Article
- The progress on stevia (Frontiers in nutrition · 2026Review
- Sucralose inhibited cell survival through the activation of ER stress in human endothelial progenitor cells.PloS one · 2026Article
- Beyond Sugar: A Holistic Review of Sweeteners and Their Role in Modern Nutrition.Foods (Basel, Switzerland) · 2025Review
- Association of sugar-sweetened, artificially sweetened, and unsweetened tea with all-cause and cause-specific mortality: a prospective cohort study in UK biobank.BMC public health · 2025Article
- Sweetened beverage intake across moderate intake range is not associated with pregnancy-related weight change or biomarkers of glycemic control.Nutrition research (New York, N.Y.) · 2025Observational
- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- Causal Effects of Artificially Sweetened Foods on Chronic Pain Mediated by Gut Microbiota: A Mendelian Randomization Study.Food science & nutrition · 2025Article
- Article
- Biosynthesis and metabolic engineering of natural sweeteners.AMB Express · 2025Review
- An integrative analysis reveals cancer risk associated with artificial sweeteners.Journal of translational medicine · 2025Article
- The Effect of Commercially Available Sugar Alternatives onInternational journal of food science · 2025Article
- Food sweeteners: Angels or clowns for human health?Current research in food science · 2025Review
- Research Progress on the Relationship Between Artificial Sweeteners and Breast Cancer.Biomedicines · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Artificial sweeteners have been developed as substitutes for sugar. Sucralose, acesulfame K (ACE K), aspartame, and saccharin are artificial sweeteners. Previously, artificial sweeteners were thought to be effective in treating obesity and diabetes. Human meta-analyses have reported that artificial sweeteners have no effect on body weight or glycemic control. However, recent studies have shown that artificial sweeteners affect glucose absorption in the intestinal tract as well as insulin and incretin secretion in humans and animals. Moreover, artificial sweeteners alter the composition of the microbiota and worsen the glycemic control owing to changes in the gut microbiota. The early intake of ACE K was also shown to suppress the taste response to sugar. Furthermore, a large cohort study showed that high artificial sweetener intake was associated with all-cause mortality, cardiovascular risk, coronary artery disease risk, cerebrovascular risk, and cancer risk. The role of artificial sweeteners in the treatment of diabetes and obesity should be reconsidered, and the replacement of sugar with artificial sweeteners in patients will require the long-term tracking of not only intake but also changes in blood glucose and weight as well as future guidance based on gut bacteria data. To utilize the beneficial properties of artificial sweeteners in treatment, further studies are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.