Evidence map›Paper›PMID 36364675›Full record

ReviewNanomaterials (Basel, Switzerland)2022

Surface Functionalization of Nanofibers: The Multifaceted Approach for Advanced Biomedical Applications.

Deepak Kulkarni, Shubham Musale, Prabhakar Panzade, Ana Cláudia Paiva-Santos, Pratiksha Sonwane, Monika Madibone, Puja Choundhe, Prabhanjan Giram, Simona Cavalu

Abstract readReview
In one paragraph

Review in Nanomaterials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Deepak KulkarniDepartment of Pharmaceutics, Srinath College of Pharmacy, Bajajnagar, Aurangabad 431136, India.ORCID 0000-0001-5992-5903
Shubham MusaleFormulation and Development Department, Aculife Healthcare Pvt. Ltd., Sachana, Ahmedabad 382150, India.
Prabhakar PanzadeDepartment of Pharmaceutics, Srinath College of Pharmacy, Bajajnagar, Aurangabad 431136, India.ORCID 0000-0003-1247-9197
Ana Cláudia Paiva-SantosDepartment of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, 3004-531 Coimbra, Portugal.ORCID 0000-0003-2710-6000
Pratiksha SonwaneDepartment of Chemistry, Srinath College of Pharmacy, Bajajnagar, Aurangabad 431136, India.
Monika MadiboneDepartment of Pharmaceutics, Srinath College of Pharmacy, Bajajnagar, Aurangabad 431136, India.
Puja ChoundheDepartment of Pharmaceutics, Srinath College of Pharmacy, Bajajnagar, Aurangabad 431136, India.
Prabhanjan GiramDepartment of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.ORCID 0000-0003-0439-1347
Simona CavaluFaculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.ORCID 0000-0001-7810-8925

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanocarriers are gaining significant importance in the modern era of drug delivery. Nanofiber technology is one of the prime paradigms in nanotechnology for various biomedical and theranostic applications. Nanofibers obtained after successful electrospinning subjected to surface functionalized for drug delivery, biomedical, tissue engineering, biosensing, cell imaging and wound dressing application. Surface functionalization entirely changes physicochemical and biological properties of nanofibers. In physicochemical properties, wettability, melting point, glass transition temperature, and initial decomposition temperature significantly change offer several advantageous for nanofibers. Similarly, biological properties include cell adhesion, biocompatibility, and proliferation, also changes by functionalization of nanofibers. Various natural and synthetic materials polymers, metals, carbon materials, functional groups, proteins, and peptides, are currently used for surface modification of nanofibers. Various research studies across the globe demonstrated the usefulness of surface functionalized nanofibers in tissue engineering, wound healing, skin cancers, melanoma, and disease diagnosis. The delivery of drug through surface functionalized nanofibers results in improved permeation and bioavailability of drug which is important for better targeting of disease and therapeutic efficacy. This review provides a comprehensive insight about various techniques of surface functionalization of nanofibers along with its biomedical applications, toxicity assessment and global patent scenario.

Indexed as

biomedical applicationselectrospinningnanofiberssurface functionalization

Identifiers

PMID36364675
PMCPMC9655053

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.