Evidence map›Paper›PMID 36364487›Full record

ArticleMolecules (Basel, Switzerland)2022

Olfactory Stimulation Successfully Modulates the Neurochemical, Biochemical and Behavioral Phenotypes of the Visceral Pain.

Wen-Chieh Liao, Rou-An Yao, Li-You Chen, Ting-Yi Renn, Igor V Klimenkov, Nikolay P Sudakov, Fu-Der Mai, Yea-Tzy Chen, Hung-Ming Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Wen-Chieh LiaoDepartment of Post Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan.
Rou-An YaoDepartment of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Li-You ChenDepartment of Anatomy, School of Medicine, College of Medicine, Chung Shan Medical University, Taichung 402306, Taiwan.
Ting-Yi RennGraduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Igor V KlimenkovDepartment of Cell Ultrastructure, Limnological Institute, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia.
Nikolay P SudakovDepartment of Cell Ultrastructure, Limnological Institute, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russia.ORCID 0000-0001-5565-5600
Fu-Der MaiDepartment of Biochemistry and Molecular Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.
Yea-Tzy ChenDepartment of Speech Language Pathology and Audiology, College of Health Technology, National Taipei University of Nursing and Health Sciences, Taipei 112303, Taiwan.
Hung-Ming ChangDepartment of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110301, Taiwan.ORCID 0000-0002-4554-6854
Taipei Medical University · TWSiberian Branch of the Russian Academy of Sciences · RUChung Shan Medical University · TWHiroshima University · JPNational Chung Hsing University · TWNational Taipei University of Nursing and Health Science · TW

Funding

Ministry of Science and Technology, Taiwan MOST 111-2314-B-038-101
6 · The paper itself

Abstract

Visceral pain (VP) is the organ-derived nociception in which increased inflammatory reaction and exaggerated activation of the central nucleus of the amygdala (CeA) may contribute to this deficiency. Considering the amygdala also serves as the integration center for olfaction, the present study aimed to determine whether olfactory stimulation (OS) would effectively depress over-activation and inflammatory reaction in CeA, and successfully relieve VP-induced abnormalities. Adult rats subjected to intraperitoneal injection of acetic acid inhaled lavender essential oil for 2 or 4 h. The potential benefits of OS were determined by measuring the pro-inflammatory cytokine level, intracellular potassium and the upstream small-conductance calcium-activated potassium (SK) channel expression, together with detecting the stress transmitters that participated in the modulation of CeA activity. Results indicated that in VP rats, strong potassium intensity, reduced SK channel protein level, and increased corticotropin-releasing factor, c-fos, and substance P immuno-reactivities were detected in CeA. Enhanced CeA activation corresponded well with increased inflammatory reaction and decreased locomotion, respectively. However, in rats subjected to VP and received OS, all above parameters were significantly returned to normal levels with higher change detected in treating OS of 4h. As OS successfully depresses inflammation and CeA over-activation, application of OS may serve as an alternative and effective strategy to efficiently relieve VP-induced deficiency.

Indexed as

Visceral PainAnimalsCorticotropin-Releasing HormonePhenotypePotassiumRatsSmellCorticotropin-Releasing HormonePotassiumcentral nucleus of amygdalainflammationneurochemical phenotypesolfactory stimulationtime-of-flight secondary ion mass spectrometry (TOF-SIMS)visceral pain

Identifiers

PMID36364487
PMCPMC9655738
OpenAlexW4308531858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.