Evidence map›Paper›PMID 36364437›Full record

ArticleMolecules (Basel, Switzerland)2022

The SWGEDWGEIW from Soybean Peptides Reduce Oxidative Damage-Mediated Apoptosis in PC-12 Cells by Activating SIRT3/FOXO3a Signaling Pathway.

Guofu Yi, Mengyue Zhou, Qingfei Du, Shuibing Yang, Yuxia Zhu, Yining Dong, Yang Liu, He Li, You Li, Xinqi Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Guofu YiCollege of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.ORCID 0000-0002-9018-0679
Mengyue ZhouCollege of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.
Qingfei DuCollege of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.
Shuibing YangCollege of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.
Yuxia ZhuCollege of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.
Yining DongCollege of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.
Yang LiuCollege of Biology and Food Engineering, Chuzhou University, Chuzhou 239000, China.
He LiBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China.ORCID 0000-0001-7459-9202
You LiBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China.
Xinqi LiuBeijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University (BTBU), Beijing 100048, China.
Chuzhou University · CNBeijing Technology and Business University · CN

Funding

Chuzhou University scientific research fund 2020qd34the Open Project Program of the National Soybean Processing Industry Technology Innovation Center, Beijing Technology and Business University DDJGCY001
6 · The paper itself

Abstract

The goal of the investigation was to study the protective effects of the SWGEDWGEIW (the single peptide, TSP) from soybean peptides (SBP) on hydrogen peroxide (H2O2)-induced apoptosis together with mitochondrial dysfunction in PC-12 cells and their possible implications to protection mechanism. Meanwhile, the SBP was used as a control experiment. The results suggested that SBP and TSP significantly (p < 0.05) inhibited cellular oxidative damage and ROS-mediated apoptosis. In addition, SBP and TSP also enhanced multiple mitochondrial biological activities, decreased mitochondrial ROS levels, amplified mitochondrial respiration, increased cellular maximal respiration, spare respiration capacity, and ATP production. In addition, SBP and TSP significantly (p < 0.05) raised the SIRT3 protein expression and the downstream functional gene FOXO3a. In the above activity tests, the activity of TSP was slightly higher than that of SBP. Taken together, our findings suggested that SBP and TSP can be used as promising nutrients for oxidative damage reduction in neurons, and TSP is more effective than SBP. Therefore, TSP has the potential to replace SBP and reduce neuronal oxidative damage.

Indexed as

Sirtuin 3ApoptosisGlycine maxHydrogen PeroxideOxidative StressPeptidesReactive Oxygen SpeciesSignal TransductionHydrogen PeroxidePeptidesReactive Oxygen SpeciesSirtuin 3mitochondrial dysfunctionneuronal oxidative damagePC-12 cellssoybean peptidesSWGEDWGEIW

Identifiers

PMID36364437
PMCPMC9657979
OpenAlexW4308446560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.