Evidence map›Paper›PMID 36364423›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis, Structure and Molecular Docking of New 4,5-Dihydrothiazole Derivatives Based on 3,5-Dimethylpyrazole and Cytisine and Salsoline Alkaloids.

Marat K Ibrayev, Oralgazy A Nurkenov, Zhanar B Rakhimberlinova, Altynaray T Takibayeva, Irina V Palamarchuk, Dastan M Turdybekov, Assel A Kelmyalene, Ivan V Kulakov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marat K IbrayevDepartment of Chemistry and Chemical Technology, Abylkas Saginov Karaganda Technical University, Ave. Nursultan Nazarbayev, 56, Karaganda 100027, Kazakhstan.ORCID 0000-0003-0798-5562
Oralgazy A NurkenovDepartment of Chemistry and Chemical Technology, Abylkas Saginov Karaganda Technical University, Ave. Nursultan Nazarbayev, 56, Karaganda 100027, Kazakhstan.
Zhanar B RakhimberlinovaDepartment of Chemistry and Chemical Technology, Abylkas Saginov Karaganda Technical University, Ave. Nursultan Nazarbayev, 56, Karaganda 100027, Kazakhstan.
Altynaray T TakibayevaDepartment of Chemistry and Chemical Technology, Abylkas Saginov Karaganda Technical University, Ave. Nursultan Nazarbayev, 56, Karaganda 100027, Kazakhstan.ORCID 0000-0003-0536-0817
Irina V PalamarchukInstitute of Chemistry, Tyumen State University, 15a Perekopskaya St., Tyumen 625003, Russia.ORCID 0000-0003-3376-6953
Dastan M TurdybekovDepartment of Chemistry and Chemical Technology, Abylkas Saginov Karaganda Technical University, Ave. Nursultan Nazarbayev, 56, Karaganda 100027, Kazakhstan.
Assel A KelmyaleneDepartment of Chemistry and Chemical Technology, Abylkas Saginov Karaganda Technical University, Ave. Nursultan Nazarbayev, 56, Karaganda 100027, Kazakhstan.
Ivan V KulakovInstitute of Chemistry, Tyumen State University, 15a Perekopskaya St., Tyumen 625003, Russia.ORCID 0000-0001-5772-2096

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan AP08052014
6 · The paper itself

Abstract

The interaction results of 1,2-dibromo-3-isothiocyanatopropane with some pyrazoles as well as cytisine and salsoline alkaloids were presented in this paper. It was shown that the reaction resulted in one one-step and rather mild method for the preparation of the corresponding 1,3-thiazoline bromomethyl derivatives. The yield of this reaction was affected by the presence of a base and an order in which reagents were added. Molecular docking of the synthesized 1,3-thiazoline derivatives for putative antibacterial activity was carried out using the penicillin-binding target protein (PBP4) of the bacteria

Indexed as

AlkaloidsSalsoline AlkaloidsEscherichia coliMolecular Docking SimulationMolecular StructurePyrazolesQuinolizidine AlkaloidsStaphylococcus aureusStructure-Activity Relationship3,5-dimethylpyrazoleAlkaloidscytisinePyrazolesQuinolizidine AlkaloidsSalsoline Alkaloids1,2-dibromo-3-isothiocyanatopropane3,5-dimethyl-1H-pyrazole5-(bromomethyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-4,5-dihydrothiazoleallylisothiocyanatecytisine and salsoline alkaloidsintramolecular heterocyclization

Identifiers

PMID36364423
PMCPMC9655236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.