ReviewMolecules (Basel, Switzerland)2022
Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases.
Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
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- Phenolic-Enriched Ethyl Acetate Fraction of Chatuphalatika Inhibits HMG-CoA Reductase and Preferentially Improves Hepatic Metabolic Parameters in High-Fat Diet-Fed Mice.Molecules (Basel, Switzerland) · 2026Article
- Tannins as Therapeutic Agents for Ulcerative Colitis: Mechanisms and Prospects in Regulating Gut Inflammatory-Oxidative Homeostasis.Molecules (Basel, Switzerland) · 2026Review
- Valorization of Chestnut By-Products: Extraction, Bioactivity, and Applications of Shells, Spiny Burs, and Leaves.Life (Basel, Switzerland) · 2026Review
- LncRNA PELATON regulates Th2 cell differentiation by miR-10b-5p/GATA3 axis in allergic rhinitis.The World Allergy Organization journal · 2025Article
- A multifunctional hydrogel system with synergistic effects againstMaterials today. Bio · 2025Article
- Phytochemical-based therapeutics from traditional eastern medicine: analgesic effects and ion channel modulation.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Hydroethanolic Extract ofTheScientificWorldJournal · 2025Article
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- Investigation into the Anti-Acne Effects ofInternational journal of molecular sciences · 2024Article
- Effects of Diet Supplemented With Hydrolyzable Tannin on the Growth Performance, Antioxidant Capacity, and Muscle Nutritional Quality of JuvenileAquaculture nutrition · 2024Article
- In Vitro Biotransformation and Anti-Inflammatory Activity of Constituents and Metabolites ofPharmaceutics · 2023Article
- Ellagitannins fromNutrients · 2023Article
- Association ofFrontiers in pediatrics · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Plants rich in hydrolyzable tannins were traditionally used all over the world for a variety of chronic inflammatory disorders, including arthritis, colitis, and dermatitis. However, the knowledge of their immunological targets is still limited though fundamental for their rational use in phytotherapy. The recent advances regarding the pathogenesis of inflammatory-based diseases represent an opportunity to elucidate the pharmacological mechanism of plant-derived metabolites with immunomodulatory activity. This review collects recent articles regarding the role of hydrolyzable tannins and their gut metabolites in Th1, Th2, and Th17 inflammatory responses. In line with the traditional use, rheumatoid arthritis (RA), inflammatory bowel diseases (IBDs), psoriasis, atopic dermatitis (AD), and asthma were the most investigated diseases. A substantial body of in vivo studies suggests that, beside innate response, hydrolyzable tannins may reduce the levels of Th-derived cytokines, including IFN-γ, IL-17, and IL-4, following oral administration. The mode of action is multitarget and may involve the impairment of inflammatory transcription factors (NF-κB, NFAT, STAT), enzymes (MAPKs, COX-2, iNOS), and ion channels. However, their potential impact on pathways with renewed interest for inflammation, such as JAK/STAT, or the modulation of the gut microbiota demands dedicate studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.