ArticleMolecules (Basel, Switzerland)2022
First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Comparative Analysis of Chemical Composition and Antibacterial Activity of Artemisia argyi and Artemisia lavandulifolia Hydrosols.Chemistry & biodiversity · 2026Article
- Ceratonia siliqua: Phytochemistry, Bioactivity, and Its Emerging Role as a Sustainable Food and Industrial Resource.Journal of food science · 2026Review
- Nano-Enabled Advances in Tea Tree Essential Oil (Materials (Basel, Switzerland) · 2026Review
- Review
- Ultrasound Pretreatment and Microwave-Assisted Hydrodistillation for the Extraction of Pinus pumila Needle Essential Oil: Rich in Terpenoids and High Bioactivity.Chemistry & biodiversity · 2026Article
- Electrospinning of Natural Polymeric Fibers with Essential Oils for the Control of Multidrug-Resistant Pathogens.Polymers · 2026Review
- Synergistic antipersister, efflux inhibitory & antibiofilm activities of vaginal Lactobacillus-derived postbiotics against UPEC: toward a novel therapeutic for utis.Scientific reports · 2026Article
- Antibacterial mechanism of pulsed electric field-assisted extracted volatile oil fromFrontiers in microbiology · 2026Article
- Dual action of herbal compounds inFrontiers in immunology · 2026Review
- Restoring colistin sensitivity in colistin-resistant gram-negative bacteria: combinatorial use of α-terpineol and colistin.Microbiology spectrum · 2025Article
- Antimicrobial, synergistic and antibiofilm activities of Myristica fragrans Houtt. Bioactive compounds and their derivatives.Scientific reports · 2025Article
- Human vaginal Lactobacillus Jensenii -derived (-)-Terpinen-4-ol restores antibiotic sensitivity by inhibiting efflux pumps in drug resistant E. coli and K. pneumoniae.Scientific reports · 2025Article
- Preliminary Evaluation of the Synergistic Antibacterial Effects of Selected Commercial Essential Oil Compounds Against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025Article
- Newly isolated terpenoids (covering 2019-2024) from Aspergillus species and their potential for the discovery of novel antimicrobials.Natural products and bioprospecting · 2025Review
- Aromatic Herbs as a Source of Bioactive Compounds: An Overview of Their Antioxidant Capacity, Antimicrobial Activity, and Major Applications.Molecules (Basel, Switzerland) · 2025Review
- Synergistic Antimicrobial Effects of Melaleuca alternifolia Essential Oil and Kojic Acid Combinations.Current microbiology · 2025Article
- Antimicrobial and immunomodulatory activity of natural bioactive compounds - anFrontiers in immunology · 2025Article
- Targeted inhibition ofFrontiers in microbiology · 2025Article
- Synergism Between α-Terpineol and Terpinen-4-ol Potentiates Antivirulence Response AgainstIndian journal of microbiology · 2024Article
- Essential oils: a potential alternative with promising active ingredients for pharmaceutical formulations in chronic wound management.Inflammopharmacology · 2024Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial resistance is a major public health issue raising growing concern in the face of dwindling response options. It is therefore urgent to find new anti-infective molecules enabling us to fight effectively against ever more numerous bacterial infections caused by ever more antibiotic-resistant bacteria. In this quest for new antibacterials, essential oils (or compounds extracted from essential oils) appear to be a promising therapeutic option. In the present work, we investigate the potential antibacterial synergy between a combination of terpinen-4-ol and α-terpineol (10:1) compared to standard tea tree oil. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. Then, time kill assays, in vitro cytotoxicity and bactericidal activity on latent bacteria (persisters) were investigated. Finally, an in silico study of the pharmacokinetic parameters of α-terpineol was also performed. Altogether, our data demonstrate that the combination of terpinen-4-ol and α-terpineol might be a precious weapon to address ESKAPE pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.