Evidence map›Paper›PMID 36364263›Full record

ArticleMolecules (Basel, Switzerland)2022

Óscar M Bautista-Aguilera, José M Alonso, Marco Catto, Isabel Iriepa, Damijan Knez, Stanislav Gobec, José Marco-Contelles

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. (Molecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Óscar M Bautista-AguileraUniversidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica, Ctra, Madrid-Barcelona Km 33.6, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0000-0002-1327-1681
José M AlonsoUniversidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica, Ctra, Madrid-Barcelona Km 33.6, 28871 Alcalá de Henares, Madrid, Spain.
Marco CattoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Via E. Orabona 4, 70125 Bari, Italy.ORCID 0000-0002-8411-304X
Isabel IriepaUniversidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica, Ctra, Madrid-Barcelona Km 33.6, 28871 Alcalá de Henares, Madrid, Spain.ORCID 0000-0003-3475-9624
Damijan KnezUniversity of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia.ORCID 0000-0001-9917-1384
Stanislav GobecUniversity of Ljubljana, Faculty of Pharmacy, Askerceva 7, 1000 Ljubljana, Slovenia.ORCID 0000-0002-9678-3083
José Marco-ContellesLaboratory of Medicinal Chemistry (IQOG, CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

Funding

Slovenian Research Agency ARRS (core program funding P1-0208). P1-0208
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex disorder characterized by impaired neurotransmission in cholinergic and monoaminergic neurons, which, in combination with the accumulation of misfolded proteins and increased oxidative stress, leads to the typical features of the disease at the biomolecular level. Given the limited therapeutic success of approved drugs, it is imperative to explore rationally supported therapeutic approaches to combat this disease. The search for novel scaffolds that bind to different receptors and inhibit AD disease-related enzymes could lead to new therapeutic solutions. Here, we describe

Indexed as

Alzheimer DiseaseMonoamine OxidaseAcetylcholinesteraseAmyloid beta-PeptidesAntioxidantsCholinesterase InhibitorsCholinesterasesCoumaric AcidsHumansLigandsMonoamine Oxidase InhibitorsAcetylcholinesteraseAmyloid beta-PeptidesAntioxidantsCholinesterase InhibitorsCholinesterasesCoumaric Acidsferulic acidLigandsMonoamine OxidaseMonoamine Oxidase Inhibitorsantioxidantcholinesterasesferulic acidmolecular modellingmonoamine oxidaseradical-scavenger

Identifiers

PMID36364263
PMCPMC9655428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.