The Changes in Cyanobacterial Concentration of β-Methylamino-L-Alanine during a Bloom Event.

Siobhan J Peters, Kenneth J Rodgers, Simon M Mitrovic, David P Bishop

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.7field-weighted citation impact, top 32% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Microbial Diversity Impacts Non-Protein Amino Acid Production in Cyanobacterial Bloom Cultures Collected from Lake Winnipeg.Toxins · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Siobhan J PetersHyphenated Mass Spectrometry Laboratory (HyMaS), Faculty of Science, The University of Technology Sydney, Ultimo, NSW 2007, Australia.ORCID 0000-0003-0140-2688

Kenneth J RodgersSchool of Life Sciences, Faculty of Science, The University of Technology Sydney, Ultimo, NSW 2007, Australia.ORCID 0000-0002-3627-9651

Simon M MitrovicSchool of Life Sciences, Faculty of Science, The University of Technology Sydney, Ultimo, NSW 2007, Australia.

David P BishopHyphenated Mass Spectrometry Laboratory (HyMaS), Faculty of Science, The University of Technology Sydney, Ultimo, NSW 2007, Australia.

University of Technology Sydney · AU

Funding

Ian Potter Foundation NA

6 · The paper itself

Abstract

β-N-methylamino L-alanine (BMAA) is a neurotoxin linked to high incidences of neurodegenerative disease. The toxin, along with two of its common isomers, 2,4-diaminobuytric acid (2,4-DAB) and N-(2-aminoethyl)glycine (AEG), is produced by multiple genera of cyanobacteria worldwide. Whilst there are many reports of locations and species of cyanobacteria associated with the production of BMAA during a bloom, there is a lack of information tracking changes in concentration across a single bloom event. This study aimed to measure the concentrations of BMAA and its isomers through the progression and end of a cyanobacteria bloom event using liquid chromatography-triple quadrupole-mass spectrometry. BMAA was detected in all samples analysed, with a decreasing trend observed as the bloom progressed. BMAA's isomers were also detected in all samples, however, they did not follow the same decreasing pattern. This study highlights the potential for current sampling protocols that measure a single time point as representative of a bloom's overall toxin content to underestimate BMAA concentration during a bloom event.

Indexed as

Amino Acids, DiaminoCyanobacteriaNeurodegenerative DiseasesChromatography, LiquidCyanobacteria ToxinsHumansAmino Acids, Diaminobeta-N-methylamino-L-alanineCyanobacteria Toxins2,4-DABalgal toxinsAustraliaBMAAcyanobacteriacyanotoxins

Identifiers

PMID36364208

DOI10.3390/molecules27217382

PMCPMC9658504

OpenAlexW4307946488

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.