Evidence map›Paper›PMID 36364195›Full record

ArticleMolecules (Basel, Switzerland)2022

Synthesis, In Vitro Biological Evaluation and In Silico Molecular Docking Studies of Indole Based Thiadiazole Derivatives as Dual Inhibitor of Acetylcholinesterase and Butyrylchloinesterase.

Shoaib Khan, Shahid Iqbal, Muhammad Taha, Fazal Rahim, Mazloom Shah, Hayat Ullah, Ali Bahadur, Hamad Alrbyawi, Ayed A Dera, Mohammed Issa Alahmdi and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Synthesis of modified Schiff base appended 1,2,4-triazole hybrids scaffolds: elucidating theZeitschrift fur Naturforschung. C, Journal of biosciences · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shoaib KhanDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.ORCID 0000-0001-5404-0954
Shahid IqbalDepartment of Chemistry, School of Natural Sciences (SNS), National University of Science and Technology (NUST), H-12, Islamabad 46000, Pakistan.ORCID 0000-0002-4607-6217
Muhammad TahaDepartment of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrah-Man Bin Faisal University, Dammam 34212, Saudi Arabia.
Fazal RahimDepartment of Chemistry, Hazara University, Mansehra 21120, Pakistan.
Mazloom ShahDepartment of Chemistry, Abbottabad University of Science and Technology (AUST), Abbottabad 22500, Pakistan.
Hayat UllahDepartment of Chemistry, University of Okara, Okara 56300, Pakistan.
Ali BahadurDepartment of Chemistry, College of Science and Technology, Wenzhou-Kean University, Wenzhou 325060, China.ORCID 0000-0002-5329-6277
Hamad AlrbyawiPharmaceutics and Pharmaceutical Technology Department, College of Pharmacy, Taibah University, Medina 42353, Saudi Arabia.ORCID 0000-0003-0820-3884
Ayed A DeraDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61413, Saudi Arabia.ORCID 0000-0002-6248-8983
Mohammed Issa AlahmdiDepartment of Chemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.
Rami Adel PashameahDepartment of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah 24230, Saudi Arabia.
Eman AlzahraniDepartment of Chemistry, College of Science, Taif University, Taif 21944, Saudi Arabia.
Abd-ElAziem FaroukDepartment of Biotechnology, College of Science, Taif University, Taif 21944, Saudi Arabia.

Funding

King Khalid University GRP/242/43Umm al-Qura University 22UQU4320141DSR77
6 · The paper itself

Abstract

The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (

Indexed as

AcetylcholinesteraseThiadiazolesCholinesterase InhibitorsIndolesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseCholinesterase InhibitorsIndolesThiadiazolesAchE and BuChE inhibitorsindolemolecular dockingSARthiadiazole analogs

Identifiers

PMID36364195
PMCPMC9657098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.