Evidence map›Paper›PMID 36364096›Full record

ArticleMolecules (Basel, Switzerland)2022

Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery.

Luiz Bruno De Sousa Sabino, Francesco Copes, Solène Saulais, Edy Sousa De Brito, Ivanildo José Da Silva Júnior, Tien Canh Le, Mircea Alexandru Mateescu, Diego Mantovani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Polyphenol-Loaded Liposomal Nanocarriers fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Luiz Bruno De Sousa SabinoDepartment of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil.ORCID 0000-0002-2745-5393
Francesco CopesLaboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada.ORCID 0000-0001-6901-971X
Solène SaulaisDepartment of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada.
Edy Sousa De BritoEmbrapa Agroindústria Tropical, R. Dra Sara Mesquita, 2270, Fortaleza 60511-110, Ceará, Brazil.ORCID 0000-0003-4084-8076
Ivanildo José Da Silva JúniorDepartment of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil.ORCID 0000-0002-1297-0261
Tien Canh LeDepartment of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada.
Mircea Alexandru MateescuDepartment of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada.ORCID 0000-0001-5922-4701
Diego MantovaniLaboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada.ORCID 0000-0001-9672-895X
Université du Québec à Montréal · CAUniversidade Federal do Ceará · BRUniversité Laval · CABrazilian Agricultural Research Corporation · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior PDSE 88881.135140/2016-0 (LBSS).Natural Sciences and Engineering Research Council Discovery and Alliance
6 · The paper itself

Abstract

Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.

Indexed as

AnthocyaninsExcipientsDelayed-Action PreparationsStarchTabletsAnthocyaninscarboxymethyl starchDelayed-Action PreparationsExcipientsStarchTabletsanthocyaninsbioactive agent deliverycarboxymethyl starchmonolithic tabletsSyzygium cumini

Identifiers

PMID36364096
PMCPMC9657027
OpenAlexW4307280948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.