ArticleMolecules (Basel, Switzerland)2022
Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies.
Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Exploration of the mechanism of Traditional Chinese Medicine for anxiety and depression in patients with diarrheal irritable bowel syndrome based on network pharmacology and meta-analysis.Frontiers in pharmacology · 2024Pooled it
- Anxiolytic-like effects of p-coumaric acid via GABAergic interaction pathways: an in vivo and in silico study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- 3',4'-Dihydroxyflavonol has a positive effect on the cerebellum oxidant/antioxidant system and BDNF and transmitter levels in focal brain ischemia-reperfusion.Journal of bioenergetics and biomembranes · 2026Article
- Assessment of antiemetic potential of schaftoside through modulation of dopaminergic, serotonergic and muscarinic signaling pathways: in vivo and in silico investigations.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Multitarget Neuropharmacological Actions of Drimycarpus racemosus Hook. f. GC-MS-Guided In Vivo and In Silico Evidence of Anxiolytic and Antidepressant Potential.TheScientificWorldJournal · 2026Article
- A Novel Functional Ingredient Derived From a Mixture of Mulberry (Oxidative medicine and cellular longevity · 2026Article
- Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways.ChemistryOpen · 2025Article
- Exploring the Neuroprotective Potentials of Flavonoid Metabolites inJournal of experimental pharmacology · 2025Review
- Gingerols and Shogaols ofJournal of experimental pharmacology · 2025Article
- Sclareol exerts an anti-inflammatory effect, possibly through COXs inhibition pathway:Pharmaceutical science advances · 2024Article
- Anxiolytic and Antianhedonic-like Effects ofJournal of pharmacopuncture · 2024Article
- Sedative and anxiolytic effects ofFrontiers in pharmacology · 2024Article
- Preclinical data on morpholine (3,5-di-tertbutyl-4-hydroxyphenyl) methanone induced anxiolysis.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Anxiolytic-Pharmaceuticals (Basel, Switzerland) · 2023Article
- Neuroprotective Potentials of Flavonoids: Experimental Studies and Mechanisms of Action.Antioxidants (Basel, Switzerland) · 2023Review
- Exploring the potential of intranasally administered naturally occurring quercetin loaded into polymeric nanocapsules as a novel platform for the treatment of anxiety.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Scientific evidence suggests that quercetin (QUR) has anxiolytic-like effects in experimental animals. However, the mechanism of action responsible for its anxiolytic-like effects is yet to be discovered. The goal of this research is to assess QUR's anxiolytic effects in mouse models to explicate the possible mechanism of action. After acute intraperitoneal (i.p.) treatment with QUR at a dose of 50 mg/kg (i.p.), behavioral models of open-field, hole board, swing box, and light-dark tests were performed. QUR was combined with a GABAergic agonist (diazepam) and/or antagonist (flumazenil) group. Furthermore, in silico analysis was also conducted to observe the interaction of QUR and GABA (α5), GABA (β1), and GABA (β2) receptors. In the experimental animal model, QUR had an anxiolytic-like effect. QUR, when combined with diazepam (2 mg/kg, i.p.), drastically potentiated an anxiolytic effect of diazepam. QUR is a more highly competitive ligand for the benzodiazepine recognition site that can displace flumazenil (2.5 mg/kg, i.p.). In all the test models, QUR acted similar to diazepam, with enhanced effects of the standard anxiolytic drug, which were reversed by pre-treatment with flumazenil. QUR showed the best interaction with the GABA (α5) receptor compared to the GABA (β1) and GABA (β2) receptors. In conclusion, QUR may exert an anxiolytic-like effect on mice, probably through the GABA-receptor-interacting pathway.
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