Evidence map›Paper›PMID 36363614›Full record

ArticleMembranes2022

Ameliorative Effects of Camel Milk and Its Exosomes on Diabetic Nephropathy in Rats.

Amira M Shaban, Mai Raslan, Safa H Qahl, Khaled Elsayed, Mohamed Sayed Abdelhameed, Atif Abdulwahab A Oyouni, Osama M Al-Amer, Ola Hammouda, Mohammed A El-Magd

Open access · goldAbstract read
In one paragraph

Article in Membranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Current molecular medicine · 2026
    Article
  8. Article
  9. Camel (Biology · 2025
    Review
  10. Milk-Derived Extracellular Vesicles and microRNAs: Potential Modulators of Intestinal Homeostasis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Research progress on small extracellular vesicles in diabetic nephropathy.Frontiers in cell and developmental biology · 2025
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Amira M ShabanBiotechnology & Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt.
Mai RaslanBiotechnology & Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt.
Safa H QahlDepartment of Biology, College of Science, University of Jeddah, Jeddah 21589, Saudi Arabia.ORCID 0000-0001-7599-225X
Khaled ElsayedBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.
Mohamed Sayed AbdelhameedBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.
Atif Abdulwahab A OyouniDepartment of Biology, Faculty of Sciences, University of Tabuk, Tabuk 47512, Saudi Arabia.ORCID 0000-0001-8762-4999
Osama M Al-AmerGenome and Biotechnology Unit, Faculty of Sciences, University of Tabuk, Tabuk 47512, Saudi Arabia.
Ola HammoudaBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62511, Egypt.
Mohammed A El-MagdAnatomy Department, Faculty of Veterinary Medicine, Kafrelsheikh University, El-Geish Street, Kafrelsheikh 33516, Egypt.ORCID 0000-0002-3314-9202
Beni-Suef University · EGUniversity of Tabuk · SAKafrelsheikh University · EGUniversity of Jeddah · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Contradictory results were obtained regarding the effects of extracellular vesicles such as exosomes (EXOs) on diabetes and diabetic nephropathy (DN). Some studies showed that EXOs, including milk EXOs, were involved in the pathogenesis of DN, whereas other studies revealed ameliorative effects. Compared to other animals, camel milk had unique components that lower blood glucose levels. However, little is known regarding the effect of camel milk and its EXOs on DN. Thus, the present study was conducted to evaluate this effect on a rat model of DN induced by streptozotocin. Treatment with camel milk and/or its EXOs ameliorated DN as evidenced by (1) reduced levels of kidney function parameters (urea, creatinine, retinol-binding protein (RBP), and urinary proteins), (2) restored redox balance (decreased lipid peroxide malondialdehyde (MDA) and increased the activity of antioxidants enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)), (3) downregulated expression of DN-related genes (transforming growth factor-beta 1 (

Indexed as

camel milkdiabetic nephropathyexosomesfibrosisoxidative stress

Identifiers

PMID36363614
PMCPMC9697163
OpenAlexW4307945745

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.