Evidence map›Paper›PMID 36362880›Full record

ArticleLife (Basel, Switzerland)2022

Safety and Efficacy of Rivaroxaban as Extended-Phase Anticoagulation in Patients with Cancer and Venous Thromboembolism: A Preliminary Data Analysis from the Mac Project.

Enrico Bernardi, Giuseppe Camporese, Cristiano Bortoluzzi, Franco Noventa, Davide Ceccato, Chiara Tonello, Stefania Vohong, Elena Campello, Chiara Simion, Egidio Imbalzano and 3 more

Open access · goldAbstract read
In one paragraph

Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Enrico BernardiEmergency Department, Cà Foncello Hospital, Azienda Ulss 2 Marca Trevigiana, Piazzale Ospedale 1, 31100 Treviso, Italy.
Giuseppe CamporeseUO Internal Medicine, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padova, Italy.ORCID 0000-0002-0881-5429
Cristiano BortoluzziInternal Medicine, San Giovanni e Paolo Hospital, Azienda Ulss 3 Serenissima, Via Don Tosatto 147, 30174 Mestre, Italy.
Franco NoventaQUOVADIS No-Profit Association, Studio Coppola, Galleria Ezzelino 5, 35139 Padova, Italy.
Davide CeccatoUnit of Angiology, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padova, Italy.
Chiara TonelloUnit of Angiology, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padova, Italy.
Stefania VohongInternal Medicine, San Giovanni e Paolo Hospital, Azienda Ulss 3 Serenissima, Via Don Tosatto 147, 30174 Mestre, Italy.
Elena CampelloUO Thromboembolic Disease, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padova, Italy.ORCID 0000-0002-0377-3741
Chiara SimionUO Thromboembolic Disease, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padova, Italy.
Egidio ImbalzanoDepartment of Clinical and Experimental Medicine, Polyclinic Hospital University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy.ORCID 0000-0003-2656-5467
Pierpaolo Di MiccoInternal Medicine, "A. Rizzoli" Polyclinic Hospital, Azienda NA2 Nord, Via Fundera 2, 80076 Lacco Ameno, Italy.ORCID 0000-0002-8484-4598
Elena CallegariUO Internal Medicine 2, Cà Foncello Hospital, Azienda Ulss 2 Marca Trevigiana, Piazzale Ospedale 1, 31100 Treviso, Italy.
Paolo SimioniUO Thromboembolic Disease, Azienda Ospedaliera di Padova, Via Giustiniani 2, 35128 Padova, Italy.ORCID 0000-0002-6744-383X
Azienda Ospedale - Università Padova · ITCa' Foncello Hospital · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extended-phase anticoagulation with direct oral Xa inhibitors (OAXI) is suggested in patients with cancer-associated venous thromboembolism (CAT). We report on patients enrolled in the MAC (Monitoring AntiCoagulants) Project, given rivaroxaban as extended-phase anticoagulation after CAT. The primary efficacy outcome was the incidence of symptomatic recurrent VTE; the primary safety outcomes were incidence of major and non-major clinically relevant bleeding, adverse events, and all-cause mortality. The mean patients' follow-up was 19 months (SD 16); 64/604 (11%) had CAT. Recurrent VTE occurred in 9.3% and in 8.1% of patients with and without CAT (OR 1.2, 95% CI 0.5 to 2.9;

Indexed as

cancer-related venous thromboembolismextended-phase anticoagulationfactor Xa inhibitorsreal-life

Identifiers

PMID36362880
PMCPMC9699076
OpenAlexW4307946553

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.