Evidence map›Paper›PMID 36362788›Full record

ArticleJournal of clinical medicine2022

Early Changes in Androgen Levels in Individuals with Spinal Cord Injury: A Longitudinal SwiSCI Study.

Oche Adam Itodo, Peter Francis Raguindin, Jens Wöllner, Inge Eriks-Hoogland, Xavier Jordan, Margret Hund-Georgiadis, Taulant Muka, Jürgen Pannek, Jivko Stoyanov, Marija Glisic

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Oche Adam ItodoSwiss Paraplegic Research, 6207 Nottwil, Switzerland.
Peter Francis RaguindinSwiss Paraplegic Research, 6207 Nottwil, Switzerland.ORCID 0000-0001-9716-4746
Jens WöllnerSwiss Paraplegic Centre, 6207 Nottwil, Switzerland.
Inge Eriks-HooglandSwiss Paraplegic Centre, 6207 Nottwil, Switzerland.
Xavier JordanClinique Romande de Réadaptation, 1950 Sion, Switzerland.ORCID 0000-0003-3389-0057
Margret Hund-GeorgiadisCenter for Neurorehabilitation and Paraplegiology, REHAB Basel, 4055 Basel, Switzerland.ORCID 0000-0002-4415-2888
Taulant MukaInstitute of Social and Preventive Medicine, University of Bern, 3012 Bern, Switzerland.
Jürgen PannekSwiss Paraplegic Centre, 6207 Nottwil, Switzerland.
Jivko StoyanovSwiss Paraplegic Research, 6207 Nottwil, Switzerland.
Marija GlisicSwiss Paraplegic Research, 6207 Nottwil, Switzerland.
University of Bern · CHSwiss Paraplegic Research · CHClinique Romande de Réadaptation · CHSwiss Paraplegic Center · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to explore longitudinal changes in androgen levels in individuals with spinal cord injury (SCI) within initial inpatient rehabilitation stay and identify clinical/injury characteristics associated with hormone levels. Linear regression analysis was applied to explore the association between personal/injury characteristics and androgen hormones (total testosterone, free testosterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S)) at admission to rehabilitation. Longitudinal changes in androgen levels were studied using linear mixed models. Analyses were stratified by sex and by injury type. We included 70 men and 16 women with SCI. We observed a non-linear association between age, time since injury, and androgens at baseline. At admission to initial rehabilitation, mature serum SHBG (full-length, protein form which lacks the N-terminal signaling peptide) was higher, while DHEA and DHEA-S were lower among opioid users vs. non-users. Serum levels of total testosterone and DHEA-S increased over rehabilitation period [β 3.96 (95%CI 1.37, 6.56),

Indexed as

androgensdehydroepiandrosteronedehydroepiandrosterone sulfaterehabilitationsex hormone-binding globulinspinal cord injurytestosterone

Identifiers

PMID36362788
PMCPMC9655492
OpenAlexW4308509951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.