Evidence map›Paper›PMID 36362722›Full record

ArticleJournal of clinical medicine2022

Benefits and Challenges of the Use of Two Novel vB_Efa29212_2e and vB_Efa29212_3e Bacteriophages in Biocontrol of the Root Canal

Magdalena Moryl, Aleksandra Palatyńska-Ulatowska, Agnieszka Maszewska, Iwona Grzejdziak, Silvia Dias de Oliveira, Marieli Chitolina Pradebon, Liviu Steier, Antoni Różalski, Jose Antonio Poli de Figueiredo

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

  1. Viruses · 2026
    Article
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  4. Isolation and Characterization ofCurrent issues in molecular biology · 2025
    Article
  5. Article
  6. Article
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  8. Article
  9. Anti-Infection of Oral Microorganisms from Herbal Medicine ofDrug design, development and therapy · 2024
    Review
  10. How Do Phages Disrupt the Structure ofInternational journal of molecular sciences · 2023
    Article
  11. Enterococcal Phages: Food and Health Applications.Antibiotics (Basel, Switzerland) · 2023
    Review
  12. Review
  13. Efficacy of Calcium Hydroxide/Saline versus Calcium Hydroxide/International journal of dentistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Magdalena MorylDepartment of Biology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Aleksandra Palatyńska-UlatowskaDepartment of Endodontics, Chair of Conservative Dentistry and Endodontics, Medical University of Lodz, 92-213 Lodz, Poland.ORCID 0000-0003-0171-8594
Agnieszka MaszewskaDepartment of Biology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Iwona GrzejdziakDepartment of Biology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Silvia Dias de OliveiraLaboratory of Immunology and Microbiology, School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre 90619-900, Brazil.ORCID 0000-0002-7296-5085
Marieli Chitolina PradebonDepartment of Morphological Sciences, Federal University of Rio Grande do Sul - UFRGS, Porto Allegre 90010-150, Brazil.
Liviu SteierRobert Schattner Center, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-0937-9147
Antoni RóżalskiDepartment of Biology of Bacteria, Institute of Microbiology, Biotechnology and Immunology, Faculty of Biology and Environmental Protection, University of Lodz, 90-237 Lodz, Poland.
Jose Antonio Poli de FigueiredoDepartment of Morphological Sciences, Federal University of Rio Grande do Sul - UFRGS, Porto Allegre 90010-150, Brazil.ORCID 0000-0002-8113-9260
University of Łódź · PLUniversidade Federal do Rio Grande do Sul · BRMedical University of Lodz · PLPontifícia Universidade Católica do Rio Grande do Sul · BR

Funding

Medical University of Lodz No 503/2-044-02/503-21-001-18National Science Centre (NCN), Poland No 2020/04/X/NZ6/00570
6 · The paper itself

Abstract

Bacteriophage therapy has emerged as a strategy supplementing traditional disinfection protocols to fight biofilms. The aim of the study was to isolate the phages against

methods

resultsIsolated phages differed in morphology. Taxonomy for vB_Efa29212_2e (Siphoviridae, Efquatovirus) and for vB_Efa29212_3e (Herelleviridae, Kochikohdavirus) was confirmed. Both phages were stable at a temperature range of 4-50 °C and showed a different tolerance to chemicals: 15% EDTA, 1-3% sodium hypochlorite, and chlorhexidine. SEM analysis showed distortion of bacteria cells after phage inoculation, which proved the lytic activity against

conclusionsResults strongly support the concept that phage therapy has a real therapeutic potential for the prevention and treatment of

Indexed as

bacterial drug resistancebacteriophagesbiofilmendodonticsEnterococcus faecalis

Identifiers

PMID36362722
PMCPMC9658868
OpenAlexW4308128103

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.