ReviewJournal of clinical medicine2022
Vasoplegic Syndrome after Cardiopulmonary Bypass in Cardiovascular Surgery: Pathophysiology and Management in Critical Care.
Review in Journal of clinical medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Cardiopulmonary bypass versus non-bypass surgery for tumor thrombus extending into the inferior vena cava or right atrium in non-cardiac malignancies: a systematic review and meta-analysis.World journal of surgical oncology · 2025Pooled it
- The combined use of HA380 hemoperfusion in cardiopulmonary bypass alleviates postoperative inflammatory response and organ dysfunction following cardiac surgery.Journal of cardiothoracic surgery · 2026Trial
- Perioperative management of vasoplegic syndrome in cardiac surgery: a narrative review.Annals of medicine and surgery (2012) · 2026Review
- Review
- Dynamic Perioperative Risk Stratification of In-Hospital Mortality After Elective Isolated On-Pump CABG: A Single-Center Firth Penalized Logistic Regression Analysis.Journal of clinical medicine · 2026Article
- Vasoplegia in Cardiac Surgery and Mechanical Circulatory Support: From Cardiopulmonary Bypass to Advanced Circulatory Support Devices.Journal of cardiovascular development and disease · 2026Review
- Article
- Article
- From Static Risk Estimates to Dynamic Clinical Trajectories: A Conceptual Analysis of Perioperative Medicine.Health care analysis : HCA : journal of health philosophy and policy · 2026Article
- Extracorporeal Cytokine Hemadsorption with oXirisJournal of clinical medicine · 2026Article
- Article
- Association between cardiopulmonary bypass weaning time and adverse outcomes in patients with aortic dissection who underwent total arch replacement combined with stented elephant trunk implantation.BMC cardiovascular disorders · 2026Article
- Endothelin-1 and Vasomotor Tone Following Cardioplegic Ischemia/Reperfusion and Cardiopulmonary Bypass.Cells · 2026Review
- Inflammatory Cytokines as Early Predictors of Weaning Failure From Extracorporeal Life Support.Artificial organs · 2026Article
- Aortic Arch and Frozen Elephant Trunk Surgery: Anesthetic Challenges and Strategies for Organ Protection.Journal of clinical medicine · 2026Review
- The mystery of methylene blue and its role in managing post-cardiac surgery vasoplegic shock.Annals of medicine · 2025Article
- Elective Cardiopulmonary Bypass (CPB) Surgery After COVID-19: Vasoactive Needs and Early Complications-A Prospective Study.Journal of clinical medicine · 2025Article
- Impaired contractile response of human peripheral arterioles to angiotensin II after cardiopulmonary bypass.Surgery · 2025Article
- Severe Vasoplegic Syndrome Treated with Angiotensin II and Hemoadsorption Therapy after Cardiac Surgery.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Prognostic value of the vasoactive-inotropic score in predicting outcomes following LVAD implantation.JHLT open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vasoplegic syndrome (VS) is a common complication following cardiovascular surgery with cardiopulmonary bypass (CPB), and its incidence varies from 5 to 44%. It is defined as a distributive form of shock due to a significant drop in vascular resistance after CPB. Risk factors of VS include heart failure with low ejection fraction, renal failure, pre-operative use of angiotensin-converting enzyme inhibitors, prolonged aortic cross-clamp and left ventricular assist device surgery. The pathophysiology of VS after CPB is multi-factorial. Surgical trauma, exposure to the elements of the CPB circuit and ischemia-reperfusion promote a systemic inflammatory response with the release of cytokines (IL-1β, IL-6, IL-8, and TNF-α) with vasodilating properties, both direct and indirect through the expression of inducible nitric oxide (NO) synthase. The resulting increase in NO production fosters a decrease in vascular resistance and a reduced responsiveness to vasopressor agents. Further mechanisms of vasodilation include the lowering of plasma vasopressin, the desensitization of adrenergic receptors, and the activation of ATP-dependent potassium (K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.