ArticleInternational journal of molecular sciences2022
Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 194 citations in OpenAlex.
- A purified reconstituted bilayer matrix shows improved outcomes in treatment of non-healing diabetic foot ulcers when compared to the standard of care: Final results and analysis of a prospective, randomized, controlled, multi-centre clinical trial.International wound journal · 2024Trial
- HomologousMaterials today. Bio · 2026Article
- Design of a Gelatin/Carboxymethyl Cellulose Hydrogel Containing Myrtus Communis Extract with Anti-inflammatory Capabilities for Accelerated Wound Healing; in Vitro and in Vivo Study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Article
- Antibacterial and antibiofilm effects of natural phenolic acids: Insights into structure-function relationships, extracellular pH, and morphological changes.Microbiology spectrum · 2026Article
- Topical strategies for antimicrobial delivery of peptide medicines for the management of chronic wounds.Discover nano · 2026Review
- Multifunctional Hydrogels for Diabetic Wound Healing: Design Strategies and Microenvironmental Remodeling Mechanisms.Gels (Basel, Switzerland) · 2026Review
- Synthesis, characterization, shelf life and optimization of process parameter of plasma-activated hydrogel production for Staphylococcus aureus Inhibition.Scientific reports · 2026Article
- Chondroitin Sulfate-Based MPDA@MnOPolymers · 2026Article
- Intrinsically disordered protein coating for oral delivery of peptide drugs.Cell biomaterials · 2026Article
- Modifiable PEDOT:PSS-based flexible diagnostic and therapeutic dressings for personalized wound management.Microsystems & nanoengineering · 2026Article
- Flexible Polypyrrole-Based pH Sensors via Oxidative Chemical Vapor Deposition.Advanced healthcare materials · 2026Article
- Human Corneal Stromal Stem Cell Treatment Reduces Established Opacities in Chronic Corneal Scarring.Cells · 2026Article
- Advances in Nanotechnology-Assisted Delivery of TCM-Derived Bioactive Compounds for Wound Repair.Pharmaceutics · 2026Review
- Biocompatible Photocrosslinked Chitosan- and Gelatin-Based Hydrogels for Wound Healing Applications.Gels (Basel, Switzerland) · 2026Article
- pH profiling reveals progressive wound acidification during healing and higher pH in chronic non-healing wounds: a prospective, multicenter cohort study.Scientific reports · 2026Observational
- Lactic Acid-Loaded Hydrogels for Post-Episiotomy Wound Healing: Microenvironment Engineering and Regenerative Strategies-A Narrative Review.Molecules (Basel, Switzerland) · 2026Review
- The probiotic Lactiplantibacillus plantarum ATCC10241 inhibits wound-associated pathogens through the secretion of organic acids.Scientific reports · 2026Article
- Isolation, Characterization and Biological Evaluation of Collagen fromMarine drugs · 2026Article
- Lignin-Based Nanoparticles Loaded with Essential Oils: Potential for Diabetic Foot Infection Management.ACS materials Au · 2026Article
- Fermented Plant Extract-Loaded Collagen Scaffolds: Bioactive Hydrogels for Enhanced Wound Repair and Immune Modulation.Gels (Basel, Switzerland) · 2026Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
There has been little understanding of acidification functionality in wound healing, highlighting the need to study the efficacy of wound acidification on wound closure and cellular activity in non-infected wounds. This study is focused on establishing the healing potential of wound acidification in non-infected wounds. Acidic buffers, constituting either phosphoric or citric acid, were employed to modify the physiological pH of non-infected full-thickness excisional murine wounds. Acidification of the wound by acidic buffers was found to be an effective strategy to improve wound healing. A significant improvement in wound healing parameters was observed as early as 2 days post-treatment with acidic buffers compared to controls, with faster rate of epithelialization, wound closure and higher levels of collagen at day 7. pH is shown to play a role in mediating the rate of wound healing, with acidic buffers formulated at pH 4 observed to stimulate faster recovery of wounded tissues than pH 6 buffers. Our study shows the importance of maintaining an acidic wound microenvironment at pH 4, which could be a potential therapeutic strategy for wound management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.