Evidence map›Paper›PMID 36362322›Full record

ArticleInternational journal of molecular sciences2022

New Molecules of Diterpene Origin with Inhibitory Properties toward α-Glucosidase.

Elena Tretyakova, Irina Smirnova, Oxana Kazakova, Ha Thi Thu Nguyen, Alina Shevchenko, Elena Sokolova, Denis Babkov, Alexander Spasov

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Terpenes in the management of chronic kidney disease.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Elena TretyakovaUfa Institute of Chemistry, Ufa Federal Research Centre, Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054 Ufa, Russia.
Irina SmirnovaUfa Institute of Chemistry, Ufa Federal Research Centre, Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054 Ufa, Russia.
Oxana KazakovaUfa Institute of Chemistry, Ufa Federal Research Centre, Russian Academy of Sciences, 71 Prospect Oktyabrya, 450054 Ufa, Russia.ORCID 0000-0002-5606-1588
Ha Thi Thu NguyenInstitute of Chemistry, Vietnamese Academy of Science and Technology, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi 100000, Vietnam.
Alina ShevchenkoScientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya Str. 39, 400087 Volgograd, Russia.
Elena SokolovaScientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya Str. 39, 400087 Volgograd, Russia.
Denis BabkovScientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya Str. 39, 400087 Volgograd, Russia.ORCID 0000-0002-9645-3324
Alexander SpasovScientific Center for Innovative Drugs, Volgograd State Medical University, Novorossiyskaya Str. 39, 400087 Volgograd, Russia.ORCID 0000-0002-7185-4826
Volgograd State Medical University · RUUfa Institute of Chemistry · RUVietnam Academy of Science and Technology · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of diabetes mellitus (DM), one of the most common chronic metabolic disorders, has increased dramatically over the past decade and has resulted in higher rates of morbidity and mortality worldwide. The enzyme, α-Glucosidase (α-GLy), is considered a therapeutic target for the treatment of type 2 DM. Herein, we synthesized arylidene, heterocyclic, cyanoetoxy- and propargylated derivatives of quinopimaric acid (levopimaric acid diene adduct with

Indexed as

Diabetes Mellitus, Type 2Diterpenesalpha-GlucosidasesGlycoside Hydrolase InhibitorsHumansIndolesKineticsMolecular Docking SimulationMolecular StructureStructure-Activity Relationshipalpha-GlucosidasesDiterpenesGlycoside Hydrolase InhibitorsIndolesabietane diterpenoidsADMETdiabetes mellituslevopimaric acidmolecular dockingquinopimaric acidα-glucosidase

Identifiers

PMID36362322
PMCPMC9655717
OpenAlexW4308522605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.