ArticleInternational journal of molecular sciences2022
Radical Production with Pulsed Beams: Understanding the Transition to FLASH.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- Reduced corneal toxicity following whole brain irradiation in mice.Clinical and translational radiation oncology · 2026Article
- Preparation of Hydrogel by Crosslinking and Multi-Dimensional Applications.Gels (Basel, Switzerland) · 2025Review
- Influence factor and mechanism of FLASH effect.Frontiers in oncology · 2025Review
- Prediction of the treatment effect of FLASH radiotherapy with synchrotron radiation from the Circular Electron-Positron Collider (CEPC).Journal of synchrotron radiation · 2024Article
- Commissioning an ultra-high-dose-rate electron linac with end-to-end tests.Physics in medicine and biology · 2024Article
- First Monte Carlo beam model for ultra-high dose rate radiotherapy with a compact electron LINAC.Medical physics · 2024Article
- Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Ultra-high dose rate (UHDR) irradiation regimes have the potential to spare normal tissue while keeping equivalent tumoricidal capacity than conventional dose rate radiotherapy (CONV-RT). This has been called the FLASH effect. In this work, we present a new simulation framework aiming to study the production of radical species in water and biological media under different irradiation patterns. The chemical stage (heterogeneous phase) is based on a nonlinear reaction-diffusion model, implemented in GPU. After the first 1 μs, no further radical diffusion is assumed, and radical evolution may be simulated over long periods of hundreds of seconds. Our approach was first validated against previous results in the literature and then employed to assess the influence of different temporal microstructures of dose deposition in the expected biological damage. The variation of the Normal Tissue Complication Probability (NTCP), assuming the model of Labarbe et al., where the integral of the peroxyl radical concentration over time (AUC-ROO) is taken as surrogate for biological damage, is presented for different intra-pulse dose rate and pulse frequency configurations, relevant in the clinical scenario. These simulations yield that overall, mean dose rate and the dose per pulse are the best predictors of biological effects at UHDR.
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Registered trials
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