Evidence map›Paper›PMID 36362193›Full record

ArticleInternational journal of molecular sciences2022

Inhibition of Synaptic Glutamate Exocytosis and Prevention of Glutamate Neurotoxicity by Eupatilin from

Cheng-Wei Lu, Chia-Chan Wu, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang

Open access · greenAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Cheng-Wei LuDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-2217-3231
Chia-Chan WuDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.
Kuan-Ming ChiuDivision of Cardiovascular Surgery, Cardiovascular Center, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-7597-7655
Ming-Yi LeeDepartment of Medical Research, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0001-7742-9508
Tzu-Yu LinDepartment of Anesthesiology, Far-Eastern Memorial Hospital, New Taipei City 22060, Taiwan.ORCID 0000-0002-1374-5189
Su-Jane WangSchool of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan.ORCID 0000-0002-4675-0259
Pontifícia Universidade Católica de Minas Gerais · BRFar Eastern Memorial Hospital · TWFu Jen Catholic University · TW

Funding

Far Eastern Memorial Hospital Taiwan FEMH-2022-C-054Far Eastern Memorial Hospital Taiwan FEMH-2022-C-055Ministry of Science and Technology 111-2314-B-418-009-MY2Ministry of Science and Technology Taiwan MOST 110-2320-B-030-009
6 · The paper itself

Abstract

The inhibition of synaptic glutamate release to maintain glutamate homeostasis contributes to the alleviation of neuronal cell injury, and accumulating evidence suggests that natural products can repress glutamate levels and associated excitotoxicity. In this study, we investigated whether eupatilin, a constituent of

Indexed as

ArtemisiaNeurotoxicity Syndromes4-AminopyridineAnimalsCalciumCerebral CortexExocytosisFlavonoidsGlutamic AcidKainic AcidRatsRats, Sprague-DawleySynapsinsSynaptosomes4-AminopyridineCalciumeupatilinFlavonoidsGlutamic AcidKainic AcidSynapsinscortexeupatilinglutamate excitotoxicityglutamate releaseneuroprotectionsynaptosome

Identifiers

PMID36362193
PMCPMC9657139
OpenAlexW36362193

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.