Evidence map›Paper›PMID 36362190›Full record

SynthesisInternational journal of molecular sciences2022

PET-Derived Radiomics and Artificial Intelligence in Breast Cancer: A Systematic Review.

Luca Urso, Luigi Manco, Angelo Castello, Laura Evangelista, Gabriele Guidi, Massimo Castellani, Luigia Florimonte, Corrado Cittanti, Alessandro Turra, Stefano Panareo

Abstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Insights into pet-based radiogenomics in oncology: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2025
    Pooled it
  2. Pooled it
  3. The impact of PET imaging on triple negative breast cancer: an updated evidence-based perspective.European journal of nuclear medicine and molecular imaging · 2024
    Pooled it
  4. Pooled it
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  16. La Radiologia medica · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luca UrsoDepartment of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy.ORCID 0000-0002-3007-3898
Luigi MancoMedical Physics Unit, Azienda USL of Ferrara, 44124 Ferrara, Italy.ORCID 0000-0001-9338-8638
Angelo CastelloNuclear Medicine Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Laura EvangelistaDepartment of Medicine DIMED, University of Padua, 35128 Padua, Italy.ORCID 0000-0002-5955-9488
Gabriele GuidiMedical Physics Unit, University Hospital of Modena, 41125 Modena, Italy.ORCID 0000-0001-9535-9152
Massimo CastellaniNuclear Medicine Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-9217-3456
Luigia FlorimonteNuclear Medicine Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Corrado CittantiDepartment of Translational Medicine, University of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy.ORCID 0000-0002-5117-804X
Alessandro TurraMedical Physics Unit, University Hospital of Ferrara, 44124 Cona, Italy.
Stefano PanareoNuclear Medicine Unit, Oncology and Haematology Department, University Hospital of Modena, 41125 Modena, Italy.ORCID 0000-0002-9222-8752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer (BC) is a heterogeneous malignancy that still represents the second cause of cancer-related death among women worldwide. Due to the heterogeneity of BC, the correct identification of valuable biomarkers able to predict tumor biology and the best treatment approaches are still far from clear. Although molecular imaging with positron emission tomography/computed tomography (PET/CT) has improved the characterization of BC, these methods are not free from drawbacks. In recent years, radiomics and artificial intelligence (AI) have been playing an important role in the detection of several features normally unseen by the human eye in medical images. The present review provides a summary of the current status of radiomics and AI in different clinical settings of BC. A systematic search of PubMed, Web of Science and Scopus was conducted, including all articles published in English that explored radiomics and AI analyses of PET/CT images in BC. Several studies have demonstrated the potential role of such new features for the staging and prognosis as well as the assessment of biological characteristics. Radiomics and AI features appear to be promising in different clinical settings of BC, although larger prospective trials are needed to confirm and to standardize this evidence.

Indexed as

Breast NeoplasmsArtificial IntelligenceFemaleHumansPositron Emission Tomography Computed TomographyProspective StudiesAIartificial intelligencebreast cancerdeep-learningmachine-learningPET/CTpositron emission tomographyradiomics

Identifiers

PMID36362190
PMCPMC9653918

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.