Evidence map›Paper›PMID 36362173›Full record

ArticleInternational journal of molecular sciences2022

Ligand-Dependent Downregulation of Guanylyl Cyclase/Natriuretic Peptide Receptor-A: Role of miR-128 and miR-195.

Madan L Khurana, Indra Mani, Prerna Kumar, Chandramohan Ramasamy, Kailash N Pandey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Biomarkers of Cardiovascular Stress: A Historical Review.Journal of cardiovascular development and disease · 2026
    Review
  3. Article
  4. Podocyte cell-specificPhysiological genomics · 2024
    Article
  5. Discovery of another mechanism for the inhibition of particulate guanylyl cyclases by the natriuretic peptide clearance receptor.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Madan L KhuranaDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Indra ManiDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.ORCID 0000-0001-7690-5517
Prerna KumarDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Chandramohan RamasamyDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Kailash N PandeyDepartment of Physiology, School of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.
Tulane University · US

Funding

Study of ANP Receptor:Gene Targeting and ExpressionR01HL062147 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1998 to 2020
$5.0M
ANP RECEPTOR--MOLECULAR APPROACH OF SIGNALING MECHANISMSR01HL057531 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 1997 to 2013
$2.5M
ANP Receptor: Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Injury and DysfunctionR01DK133833 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI PANDEY, KAILASH N · 2022 to 2025
$1.8M
NHLBI NIH HHS R01 HL057531NHLBI NIH HHS R01 HL062147NIDDK NIH HHS R01 DK133833NIH HHS HD062147 DK133833
6 · The paper itself

Abstract

Cardiac hormones act on the regulation of blood pressure (BP) and cardiovascular homeostasis. These hormones include atrial and brain natriuretic peptides (ANP, BNP) and activate natriuretic peptide receptor-A (NPRA), which enhance natriuresis, diuresis, and vasorelaxation. In this study, we established the ANP-dependent homologous downregulation of NPRA using human embryonic kidney-293 (HEK-293) cells expressing recombinant receptor and MA-10 cells harboring native endogenous NPRA. The prolonged pretreatment of cells with ANP caused a time- and dose-dependent decrease in

Indexed as

Guanylate CyclaseMicroRNAsAtrial Natriuretic FactorCyclic GMPDown-RegulationHEK293 CellsHumansIodine RadioisotopesLigandsNatriuretic Peptide, BrainAtrial Natriuretic FactorCyclic GMPGuanylate CyclaseIodine-125Iodine RadioisotopesLigandsMicroRNAsMIRN128 microRNA, humanMIRN195 microRNA, humanNatriuretic Peptide, BrainANP-NPRA/cGMP signalingGC/NPRAHEK-293 cellsinternalizationMA-10 cells

Identifiers

PMID36362173
PMCPMC9657974
OpenAlexW4307995205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.