Evidence map›Paper›PMID 36362112›Full record

ArticleInternational journal of molecular sciences2022

Adenosine A

Silvia Sgambellone, Silvia Marri, Stefano Catarinicchia, Alessandro Pini, Dilip K Tosh, Kenneth A Jacobson, Emanuela Masini, Daniela Salvemini, Laura Lucarini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Potent and Selective Human 5-HTJournal of medicinal chemistry · 2024
    Article
  4. Lipid Trolling to Optimize AJournal of medicinal chemistry · 2024
    Article
  5. Role of histamine HInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Silvia SgambelloneDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.ORCID 0000-0002-5143-9959
Silvia MarriDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.ORCID 0000-0001-6745-8786
Stefano CatarinicchiaDepartment of Experimental and Clinical Medicine, Section of Histology, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.
Alessandro PiniDepartment of Experimental and Clinical Medicine, Section of Histology, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.ORCID 0000-0001-9828-2082
Dilip K ToshLaboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.ORCID 0000-0001-8104-1493
Emanuela MasiniDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.
Daniela SalveminiPharmacology and Physiology, Saint Louis University, School of Medicine, 1402 South Grand Blvd, St. Louis, MO 63104, USA.
Laura LucariniDepartment of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.ORCID 0000-0001-9016-8429
University of Florence · ITNational Institutes of Health · USSaint Louis University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adenosine receptors (ARs) are involved in the suppression and development of inflammatory and fibrotic conditions. Specifically, AR activation promotes differentiation of lung fibroblasts into myofibroblasts, typical of a fibrotic event. Pulmonary fibrosis is a severe disease characterized by inflammation and fibrosis of unknown etiology and lacking an effective treatment. The present investigation explored the action of MRS5980, a new, highly potent and selective A

Indexed as

Pulmonary FibrosisAdenosineAnimalsBleomycinFibroblastsFibrosisInflammationLungMiceMice, Inbred C57BLReceptors, Purinergic P1Transforming Growth Factor betaAdenosineBleomycinReceptors, Purinergic P1Transforming Growth Factor betaA3AR agonistadenosine A3 receptorinflammationlung fibrosisMRS5980

Identifiers

PMID36362112
PMCPMC9657240
OpenAlexW4308120690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.