Crystal Structure and Biochemical Analysis of a Cytochrome P450 CYP101D5 from

Pradeep Subedi, Hackwon Do, Jun Hyuck Lee, Tae-Jin Oh

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.2field-weighted citation impact, top 48% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Pradeep SubediDepartment of Life Science and Biochemical Engineering, Graduate School, Sun Moon University, Asan 31460, Korea.ORCID 0000-0002-9497-9621

Hackwon DoResearch Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon 21990, Korea.

Jun Hyuck LeeResearch Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon 21990, Korea.ORCID 0000-0002-4831-2228

Tae-Jin OhDepartment of Life Science and Biochemical Engineering, Graduate School, Sun Moon University, Asan 31460, Korea.ORCID 0000-0002-8407-5039

Korea Polar Research Institute · KRAdvanced Institute of Convergence Technology · KRSun Moon University · KR

Funding

Korea Polar Research Institute PM22030Ministry of Education NRF-2019R1D1A3A03103903

6 · The paper itself

Abstract

Cytochrome P450 enzymes (CYPs) are heme-containing enzymes that catalyze hydroxylation with a variety of biological molecules. Despite their diverse activity and substrates, the structures of CYPs are limited to a tertiary structure that is similar across all the enzymes. It has been presumed that CYPs overcome substrate selectivity with highly flexible loops and divergent sequences around the substrate entrance region. Here, we report the newly identified CYP101D5 from

Indexed as

Cytochrome P-450 Enzyme SystemSphingomonasBinding SitesCrystallography, X-RayHumansHydroxylationSubstrate SpecificityCytochrome P-450 Enzyme Systemcrystal structurecytochrome P450X-ray crystallographyα/β-ionone

Identifiers

PMID36362105

DOI10.3390/ijms232113317

PMCPMC9655578

OpenAlexW4307989178

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.