Evidence map›Paper›PMID 36362089›Full record

ArticleInternational journal of molecular sciences2022

Highly Charged Ru(II) Polypyridyl Complexes as Photosensitizer Agents in Photodynamic Therapy of Epithelial Ovarian Cancer Cells.

Luca Conti, Gina Elena Giacomazzo, Barbara Valtancoli, Mauro Perfetti, Alberto Privitera, Claudia Giorgi, Patrick Severin Sfragano, Ilaria Palchetti, Sara Pecchioli, Paola Bruni and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Luca ContiDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-0402-1293
Gina Elena GiacomazzoDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-5308-404X
Barbara ValtancoliDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.
Mauro PerfettiDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-5649-0449
Alberto PriviteraDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0002-7062-8077
Claudia GiorgiDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-1240-2405
Patrick Severin SfraganoDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-4003-0186
Ilaria PalchettiDepartment of Chemistry "Ugo Schiff", University of Florence, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-9366-0574
Sara PecchioliDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.ORCID 0000-0003-3312-0706
Paola BruniDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.ORCID 0000-0002-1151-3413
Francesca CencettiDepartment of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50134 Florence, Italy.ORCID 0000-0003-4351-2965
University of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer recurrence is frequent and associated with chemoresistance, leading to extremely poor prognosis. Herein, we explored the potential anti-cancer effect of a series of highly charged Ru(II)-polypyridyl complexes as photosensitizers in photodynamic therapy (PDT), which were able to efficiently sensitize the formation of singlet oxygen upon irradiation (

Indexed as

Antineoplastic AgentsCoordination ComplexesOvarian NeoplasmsPhotochemotherapyRutheniumCarcinoma, Ovarian EpithelialCell Line, TumorFemaleHeLa CellsHumansNeoplasm Recurrence, LocalPhotosensitizing AgentsReactive Oxygen SpeciesAntineoplastic AgentsCoordination ComplexesPhotosensitizing AgentsReactive Oxygen SpeciesRutheniumcoordination complexesdrug discoveryphototoxicityreactive oxygen species

Identifiers

PMID36362089
PMCPMC9655950
OpenAlexW4308120330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.