Evidence map›Paper›PMID 36361877›Full record

ArticleInternational journal of molecular sciences2022

RETRACTED: Characterization of the Anti-Biofilm and Anti-Quorum Sensing Activities of the β-Adrenoreceptor Antagonist Atenolol against Gram-Negative Bacterial Pathogens.

Simona Cavalu, Samar S Elbaramawi, Ahmed G Eissa, Mohamed F Radwan, Tarek S Ibrahim, El-Sayed Khafagy, Bruno Silvester Lopes, Mohamed A M Ali, Wael A H Hegazy, Mahmoud A Elfaky

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Broadly Defined Antibiotic Adjuvants forThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2026
    Review
  3. Disclosing New Insights on Pyrazolo[3,4-Journal of microbiology and biotechnology · 2025
    Article
  4. Article
  5. Reviving Furosemide as a Metallo-β-Lactamase Inhibitor against MDRJournal of microbiology and biotechnology · 2025
    Article
  6. Article
  7. Piceatannol: a renaissance in antibacterial innovation unveiling synergistic potency and virulence disruption against serious pathogens.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Assessing the antibacterial potential of 6-gingerol: Combined experimental and computational approaches.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  13. Review
  14. Article
  15. Thymoquinone is a natural antibiofilm and pathogenicity attenuating agent inFrontiers in cellular and infection microbiology · 2024
    Article
  16. Article
  17. Overview ofFrontiers in microbiology · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 5 countries.

Simona CavaluFaculty of Medicine and Pharmacy, University of Oradea, P-ta 1 Decembrie 10, 410087 Oradea, Romania.ORCID 0000-0001-7810-8925
Samar S ElbaramawiMedicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0001-8658-1296
Ahmed G EissaMedicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0002-4252-0317
Mohamed F RadwanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Tarek S IbrahimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-3049-4617
El-Sayed KhafagyDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia.ORCID 0000-0002-3741-0893
Bruno Silvester LopesSchool of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BA, UK.ORCID 0000-0002-1476-2108
Mohamed A M AliDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11432, Saudi Arabia.ORCID 0000-0001-8217-0262
Wael A H HegazyDepartment of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0001-5683-4803
Mahmoud A ElfakyDepartment of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0003-3931-9353
King Abdulaziz University · SAZagazig University · EGAin Shams University · EGSuez Canal University · EGTeesside University · GBUniversity of Oradea · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of bacterial resistance to antibiotics is an increasing public health issue that worsens with the formation of biofilms. Quorum sensing (QS) orchestrates the bacterial virulence and controls the formation of biofilm. Targeting bacterial virulence is promising approach to overcome the resistance increment to antibiotics. In a previous detailed in silico study, the anti-QS activities of twenty-two β-adrenoreceptor blockers were screened supposing atenolol as a promising candidate. The current study aims to evaluate the anti-QS, anti-biofilm and anti-virulence activities of the β-adrenoreceptor blocker atenolol against Gram-negative bacteria

Indexed as

AtenololVirulence FactorsAnimalsAnti-Bacterial AgentsBacterial ProteinsBiofilmsGram-Negative BacteriaMiceProteus mirabilisPseudomonas aeruginosaQuorum SensingSerratia marcescensAnti-Bacterial AgentsAtenololBacterial ProteinsVirulence Factorsanti-biofilmantimicrobial resistanceatenololGram-negativeQuorum sensingvirulence

Identifiers

PMID36361877
PMCPMC9656717
OpenAlexW4307610191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.