Evidence map›Paper›PMID 36361864›Full record

ArticleInternational journal of molecular sciences2022

Zohra Rahmani, Satya Surabhi, Francisca Rojo-Cortés, Amina Dulac, Andreas Jenny, Serge Birman

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Alzheimer's disease and gut-brain axis:Frontiers in neuroscience · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Advances in Drug Discovery Targeting Lysosomal Membrane Proteins.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Zohra RahmaniGenes Circuits Rhythms and Neuropathology, Brain Plasticity Unit, UMR 8249, CNRS, ESPCI Paris, PSL University, 75005 Paris, France.
Satya SurabhiDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Francisca Rojo-CortésGenes Circuits Rhythms and Neuropathology, Brain Plasticity Unit, UMR 8249, CNRS, ESPCI Paris, PSL University, 75005 Paris, France.ORCID 0000-0003-2332-8423
Amina DulacGenes Circuits Rhythms and Neuropathology, Brain Plasticity Unit, UMR 8249, CNRS, ESPCI Paris, PSL University, 75005 Paris, France.
Andreas JennyDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA.
Serge BirmanGenes Circuits Rhythms and Neuropathology, Brain Plasticity Unit, UMR 8249, CNRS, ESPCI Paris, PSL University, 75005 Paris, France.ORCID 0000-0002-4278-454X
Centre National de la Recherche Scientifique · FRAlbert Einstein College of Medicine · US

Funding

ENDOSOMAL MICROAUTOPHAGY IN DROSOPHILAR01GM119160 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JENNY, ANDREAS · 2017 to 2025
$3.9M
ESPCI ParisFondation de France 0086407NIGMS NIH HHS R01 GM119160
6 · The paper itself

Abstract

Parkinson disease (PD) is a common neurodegenerative condition affecting people predominantly at old age that is characterized by a progressive loss of midbrain dopaminergic neurons and by the accumulation of α-synuclein-containing intraneuronal inclusions known as Lewy bodies. Defects in cellular degradation processes such as the autophagy-lysosomal pathway are suspected to be involved in PD progression. The mammalian Lysosomal-associated membrane proteins LAMP1 and LAMP2 are transmembrane glycoproteins localized in lysosomes and late endosomes that are involved in autophagosome/lysosome maturation and function. Here, we show that the lack of

Indexed as

alpha-SynucleinParkinson DiseaseAnimalsDopaminergic NeuronsDrosophilaHumansLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsMammalsOxidative Stressalpha-SynucleinLAMP1 protein, humanLysosomal-Associated Membrane Protein 1Lysosomal Membrane ProteinsDrosophilaLamp1paraquatParkinson diseaseα-synuclein

Identifiers

PMID36361864
PMCPMC9657416
OpenAlexW4307944478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.