Evidence map›Paper›PMID 36361859›Full record

ArticleInternational journal of molecular sciences2022

Amelioration of Maternal Immune Activation-Induced Autism Relevant Behaviors by Gut Commensal

Tzu-Lung Lin, Cha-Chen Lu, Ting-Wen Chen, Chih-Wei Huang, Jang-Jih Lu, Wei-Fan Lai, Ting-Shu Wu, Chih-Ho Lai, Hsin-Chih Lai, Ya-Lei Chen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Characterization and Safety Evaluation of Autoclaved Gut CommensalInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Microglia and microbiome in schizophrenia: can immunomodulation improve symptoms?Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Tzu-Lung LinDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Cha-Chen LuMicrobiota Research Center and Emerging Viral Infections Research Center, Chang Gung University, Taoyuan 33302, Taiwan.
Ting-Wen ChenInstitute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0003-4028-2375
Chih-Wei HuangInstitute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Jang-Jih LuDepartment of Laboratory Medicine and Internal Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Wei-Fan LaiDepartment of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Ting-Shu WuDepartment of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-6710-3432
Chih-Ho LaiDepartment of Microbiology and Immunology, Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan 33302, Taiwan.ORCID 0000-0001-7145-784X
Hsin-Chih LaiDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.
Ya-Lei ChenDepartment of Biotechnology, National Kaohsiung Normal University, Kaohsiung 82446, Taiwan.
Chang Gung University · TWNational Yang Ming Chiao Tung University · TWAsia University · TWChang Gung University of Science and Technology · TWFu Jen Catholic University · TWLinkou Chang Gung Memorial Hospital · TWNational Kaohsiung Normal University · TW

Funding

Chang Gung Memorial Hospital CORPD1J0053, CMRPD1J0333 and CMRPD1M0081Ministry of Science and Technology, Taiwan 109-2320-B-182-034-MY3, 109-2320-B-030-010, 110-2327-B-182-001, MOST 111-2634-F-182-001
6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is characterized by cognitive inflexibility and social deficits. Probiotics have been demonstrated to play a promising role in managing the severity of ASD. However, there are no effective probiotics for clinical use. Identifying new probiotic strains for ameliorating ASD is therefore essential. Using the maternal immune activation (MIA)-based offspring ASD-like mouse model, a probiotic-based intervention strategy was examined in female mice. The gut commensal microbe

Indexed as

Autism Spectrum DisorderAutistic DisorderPrenatal Exposure Delayed EffectsAnimalsBacteroidetesBehavior, AnimalDisease Models, AnimalFemaleHumansInflammationLipopolysaccharidesMicePregnancyLipopolysaccharidesautism spectrum disorderslipopolysaccharidesmaternal immune activationnext-generation probioticParabacteroides goldsteinii

Identifiers

PMID36361859
PMCPMC9657948
OpenAlexW4307610182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.