Evidence map›Paper›PMID 36361775›Full record

ArticleInternational journal of molecular sciences2022

Application of Advanced Non-Linear Spectral Decomposition and Regression Methods for Spectroscopic Analysis of Targeted and Non-Targeted Irradiation Effects in an

Ciara Slattery, Khanh Nguyen, Laura Shields, Isabel Vega-Carrascal, Sean Singleton, Fiona M Lyng, Brendan McClean, Aidan D Meade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Detection of radiosensitive subpopulationsFrontiers in oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ciara SlatterySchool of Physics and Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin 8, Ireland.
Khanh NguyenSchool of Physics and Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin 8, Ireland.
Laura ShieldsMedical Physics Department, St. Luke's Hospital, Highfield Road, Rathgar, Dublin 6, Ireland.
Isabel Vega-CarrascalSchool of Physics and Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin 8, Ireland.
Sean SingletonSchool of Physics and Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin 8, Ireland.
Fiona M LyngSchool of Physics and Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin 8, Ireland.ORCID 0000-0002-9876-963X
Brendan McCleanMedical Physics Department, St. Luke's Hospital, Highfield Road, Rathgar, Dublin 6, Ireland.
Aidan D MeadeSchool of Physics and Clinical and Optometric Sciences, Technological University Dublin, City Campus, Dublin 8, Ireland.ORCID 0000-0003-0353-9768

Funding

Science Foundation Ireland 13/RC/2106_P2
6 · The paper itself

Abstract

Irradiation of the tumour site during treatment for cancer with external-beam ionising radiation results in a complex and dynamic series of effects in both the tumour itself and the normal tissue which surrounds it. The development of a spectral model of the effect of each exposure and interaction mode between these tissues would enable label free assessment of the effect of radiotherapeutic treatment in practice. In this study Fourier transform Infrared microspectroscopic imaging was employed to analyse an

Indexed as

Bystander EffectRadiation InjuriesCell LineCell SurvivalDNA Breaks, Double-StrandedHumansMaleextreme gradient boosting regression (XGBR)Fourier transform infrared microspectroscopy (FTIRM)out of field effectsprincipal components analysis (PCA)support vector machine (SVM)t-stochastic neighbourhood embedding (t-SNE)

Identifiers

PMID36361775
PMCPMC9654902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.